Evidence map›Paper›PMID 26702418›Full record

ArticleData in brief2015

Preferential binding of 4-hydroxynonenal to lysine residues in specific parasite proteins in plakortin-treated Plasmodium falciparum-parasitized red blood cells.

Evelin Schwarzer, Valentina Gallo, Elena Valente, Daniela Ulliers, Orazio Taglialatela-Scafati, Paolo Arese, Oleksii A Skorokhod

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Evelin SchwarzerDepartment of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
Valentina GalloDepartment of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
Elena ValenteDepartment of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
Daniela UlliersDepartment of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
Orazio Taglialatela-ScafatiDepartment of Pharmacy, University of Napoli "Federico II", Via D. Montesano 49, 80131 Napoli, Italy.
Paolo AreseDepartment of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
Oleksii A SkorokhodDepartment of Oncology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
University of Turin · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The data show the frequencies by which the amino acid residues lysine, histidine and cysteine of six proteins of the malaria parasite Plasmodium falciparum are post-translationally modified by the lipoperoxydation endproduct 4-hydroxynonenal after challenging the parasitized red blood cell with plakortin. Plakortin is an antimalarial endoperoxide whose molecular anti-parasitic effect is described in Skorokhod et al. (2015) [1]. Plakortin did not elicit hemoglobin leakage from host red blood cells and did not oxidize reduced glutathione.

Indexed as

4-hydroxynonenalantimalarial drugendoperoxideplakortinPlasmodium falciparumpost-translational modificationsred blood cell

Identifiers

PMID26702418
PMCPMC4669491
OpenAlexW2137842584

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.