ReviewProceedings. Biological sciences2015
Cardiac regeneration: epicardial mediated repair.
Review in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Bisphosphonate of Zoledronate Has Antiapoptotic Effect on Hypoxia/Reoxygenation Injury in Human Embryonic Stem Cell-Derived Cardiomyocytes Through Trk Signaling Pathway.Cell biochemistry and biophysics · 2022Article
- Pericardial Involvement in ST-Segment Elevation Myocardial Infarction as Detected by Cardiac MRI.Frontiers in cardiovascular medicine · 2022Article
- Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Article
- Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.Histology and histopathology · 2020Article
- Applications of miRNAs in cardiac development, disease progression and regeneration.Stem cell research & therapy · 2019Review
- Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells.Development (Cambridge, England) · 2019Article
- Application of Bioengineered Materials in the Surgical Management of Heart Failure.Frontiers in cardiovascular medicine · 2019Review
- Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights.Medicinal research reviews · 2018Review
- β-Catenin stabilization promotes proliferation and increase in cardiomyocyte number in chick embryonic epicardial explant culture.In vitro cellular & developmental biology. Animal · 2017Article
- Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development.PLoS genetics · 2017Article
- More than Just a Simple Cardiac Envelope; Cellular Contributions of the Epicardium.Frontiers in cell and developmental biology · 2017Review
- Neonatal Cardiac Scaffolds: Novel Matrices for Regenerative Studies.Journal of visualized experiments : JoVE · 2016Article
- Pericytes: A newly recognized player in wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2016Review
- Special feature on evolution and genetics in medicine.Proceedings. Biological sciences · 2015Article
- Wnt/β-Catenin Signaling Drives Thioacetamide-Mediated Heteroprotection Against Acetaminophen-Induced Lethal Liver Injury.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hearts of lower vertebrates such as fish and salamanders display scarless regeneration following injury, although this feature is lost in adult mammals. The remarkable capacity of the neonatal mammalian heart to regenerate suggests that the underlying machinery required for the regenerative process is evolutionarily retained. Recent studies highlight the epicardial covering of the heart as an important source of the signalling factors required for the repair process. The developing epicardium is also a major source of cardiac fibroblasts, smooth muscle, endothelial cells and stem cells. Here, we examine animal models that are capable of scarless regeneration, the role of the epicardium as a source of cells, signalling mechanisms implicated in the regenerative process and how these mechanisms influence cardiomyocyte proliferation. We also discuss recent advances in cardiac stem cell research and potential therapeutic targets arising from these studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.