ReviewProceedings. Biological sciences2015
Genomic perspectives on the evolution and spread of bacterial pathogens.
Review in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 76 citations in OpenAlex.
- Optimized Urine Metagenomic Methods Reveal Longitudinal Microbial Community Dynamics and Predictors of Transition from Asymptomatic Colonization to CAUTI.bioRxiv : the preprint server for biology · 2026Article
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- Genomic Analysis Highlights the Misinterpretation of Acquired Aminoglycoside Resistance Genes inCurrent issues in molecular biology · 2026Article
- Fast hospital discharge rates blur within-hospital 'transmission footprint' in bacterial genomes, as showcased with Staphylococcus aureus.PLoS computational biology · 2026Article
- Codon bias variation in Staphylococcus aureus.PloS one · 2026Article
- Pathogenicity and Genomic Characterization ofPathogens (Basel, Switzerland) · 2025Article
- Genomic characterization of an ESBL-producingMicrobiology spectrum · 2025Article
- Enhancing clinical microbiology for genomic surveillance of antimicrobial resistance implementation in Africa.Antimicrobial resistance and infection control · 2024Review
- Diversity analysis of livestock-associatedOpen veterinary journal · 2024Article
- No evidence that a transmissible cancer has shifted from emergence to endemism in Tasmanian devils.Royal Society open science · 2024Article
- Article
- Using source-associated mobile genetic elements to identify zoonotic extraintestinalOne health (Amsterdam, Netherlands) · 2023Article
- Characterization ofMicroorganisms · 2022Article
- An accessible, efficient and global approach for the large-scale sequencing of bacterial genomes.Genome biology · 2021Article
- In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host.Nature communications · 2021Article
- Comparison of CRISPR-Cas Immune Systems in Healthcare-Related Pathogens.Frontiers in microbiology · 2021Article
- One is not enough: On the effects of reference genome for the mapping and subsequent analyses of short-reads.PLoS computational biology · 2021Article
- Whole-genome sequencing as part of national and international surveillance programmes for antimicrobial resistance: a roadmap.BMJ global health · 2020Review
- Prevalence and characterization of Staphylococcus aureus isolated in raw milk from cows in Hokkaido, Japan.Tropical animal health and production · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 3 countries.
Funding
Abstract
Since the first complete sequencing of a free-living organism, Haemophilus influenzae, genomics has been used to probe both the biology of bacterial pathogens and their evolution. Single-genome approaches provided information on the repertoire of virulence determinants and host-interaction factors, and, along with comparative analyses, allowed the proposal of hypotheses to explain the evolution of many of these traits. These analyses suggested many bacterial pathogens to be of relatively recent origin and identified genome degradation as a key aspect of host adaptation. The advent of very-high-throughput sequencing has allowed for detailed phylogenetic analysis of many important pathogens, revealing patterns of global and local spread, and recent evolution in response to pressure from therapeutics and the human immune system. Such analyses have shown that bacteria can evolve and transmit very rapidly, with emerging clones showing adaptation and global spread over years or decades. The resolution achieved with whole-genome sequencing has shown considerable benefits in clinical microbiology, enabling accurate outbreak tracking within hospitals and across continents. Continued large-scale sequencing promises many further insights into genetic determinants of drug resistance, virulence and transmission in bacterial pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.