Evidence map›Paper›PMID 26701996›Full record

SynthesisJournal of neurology, neurosurgery, and psychiatry2016

Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis.

Frédéric Moisan, Sofiane Kab, Fatima Mohamed, Marianne Canonico, Morgane Le Guern, Cécile Quintin, Laure Carcaillon, Javier Nicolau, Nicolas Duport, Archana Singh-Manoux and 2 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurology, neurosurgery, and psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  7. Thiazolidinedione use is associated with reduced risk of Parkinson's disease in patients with diabetes: a meta-analysis of real-world evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Frédéric MoisanDépartement santé travail, Institut de veille sanitaire (InVS), Saint-Maurice, France.
Sofiane KabDépartement santé travail, Institut de veille sanitaire (InVS), Saint-Maurice, France Department of Epidemiology of ageing and age related diseases, INSERM, Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, UMRS 1018, Villejuif, France.
Fatima MohamedDepartment of Epidemiology of ageing and age related diseases, INSERM, Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, UMRS 1018, Villejuif, France.
Marianne CanonicoDepartment of Epidemiology of ageing and age related diseases, INSERM, Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, UMRS 1018, Villejuif, France.
Morgane Le GuernDépartement santé travail, Institut de veille sanitaire (InVS), Saint-Maurice, France.
Cécile QuintinDépartement des maladies chroniques et des traumatismes, Institut de veille sanitaire (InVS), Saint-Maurice, France.
Laure CarcaillonDépartement des maladies chroniques et des traumatismes, Institut de veille sanitaire (InVS), Saint-Maurice, France.
Javier NicolauInstitut de veille sanitaire (InVS), Direction scientifique et de la qualité, Saint-Maurice, France.
Nicolas DuportDépartement des maladies chroniques et des traumatismes, Institut de veille sanitaire (InVS), Saint-Maurice, France.
Archana Singh-ManouxDepartment of Epidemiology of ageing and age related diseases, INSERM, Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, UMRS 1018, Villejuif, France.
Marjorie Boussac-ZarebskaInstitut de veille sanitaire (InVS), Direction scientifique et de la qualité, Saint-Maurice, France.
Alexis ElbazDépartement santé travail, Institut de veille sanitaire (InVS), Saint-Maurice, France Department of Epidemiology of ageing and age related diseases, INSERM, Centre for Research in Epidemiology and Population Health, U1018, Villejuif, France University Paris-Sud, UMRS 1018, Villejuif, France.

Funding

Socio-economic status and heterogeneity in agingR01AG013196 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI MARMOT, MICHAEL G, SINGH-MANOUX, ARCHANA · 1996 to 2013
$3.5M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
Medical Research Council G0902037NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG034454
6 · The paper itself

Abstract

backgroundParkinson's disease (PD) is 1.5 times more frequent in men than women. Whether age modifies this ratio is unclear. We examined whether male-to-female (M-F) ratios change with age through a French nationwide prevalence/incidence study (2010) and a meta-analysis of incidence studies.

methodsWe used French national drug claims databases to identify PD cases using a validated algorithm. We computed M-F prevalence/incidence ratios overall and by age using Poisson regression. Ratios were regressed on age to estimate their annual change. We identified all PD incidence studies with age/sex-specific data, and performed a meta-analysis of M-F ratios.

resultsOn the basis of 149 672 prevalent (50% women) and 25 438 incident (49% women) cases, age-standardised rates were higher in men (prevalence=2.865/1000; incidence=0.490/1000 person-years) than women (prevalence=1.934/1000; incidence=0.328/1000 person-years). The overall M-F ratio was 1.48 for prevalence and 1.49 for incidence. Prevalence and incidence M-F ratios increased by 0.05 and 0.14, respectively, per 10 years of age. Incidence was similar in men and women under 50 years (M-F ratio <1.2, p>0.20), and over 1.6 (p<0.001) times higher in men than women above 80 years (p trend <0.001). A meta-analysis of 22 incidence studies (14 126 cases, 46% women) confirmed that M- F ratios increased with age (0.26 per 10 years, p trend=0.005).

conclusionsAge-increasing M-F ratios suggest that PD aetiology changes with age. Sex-related risk/protective factors may play a different role across the continuum of age at onset. This finding may inform aetiological PD research.

Indexed as

Sex DistributionAdultAlgorithmsAntiparkinson AgentsCohort StudiesDatabases, FactualFemaleFranceHumansMaleMiddle AgedParkinson DiseasePrevalenceRiskAntiparkinson AgentsEPIDEMIOLOGYPARKINSON'S DISEASESTATISTICS

Identifiers

PMID26701996
PMCPMC5013115

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.