ArticleeLife2015
Genetic variation in offspring indirectly influences the quality of maternal behaviour in mice.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring the interactions of antihistamine with retinoic acid receptor beta (RARB) by molecular dynamics simulations and genome-wide meta-analysis.Journal of molecular graphics & modelling · 2023Pooled it
- Offspring genetic diversity regulates rearing experiences that predict differential susceptibility to Chd8 haploinsufficiency.Communications biology · 2026Article
- Male caregiving experience alters hippocampal neuroplasticity and transcription independent of reproduction in a biparental species.Communications biology · 2025Article
- Deepening insights into cholinergic agents for intraocular pressure reduction: systems genetics, molecular modeling, andFrontiers in molecular biosciences · 2024Article
- Genetic variance and indirect genetic effects for affiliative social behavior in a wild primate.Evolution; international journal of organic evolution · 2023Article
- Indirect Genetic Effects: A Cross-disciplinary Perspective on Empirical Studies.The Journal of heredity · 2022Article
- Dissecting indirect genetic effects from peers in laboratory mice.Genome biology · 2021Article
- Systematic analysis of goal-related movement sequences during maternal behaviour in a female mouse model for Rett syndrome.The European journal of neuroscience · 2021Article
- The role of interindividual licking received and dopamine genotype on later-life licking provisioning in female rat offspring.Brain and behavior · 2021Article
- Article
- The genetic mechanism of selfishness and altruism in parent-offspring coadaptation.Science advances · 2020Article
- Strain differences in maternal neuroendocrine and behavioral responses to stress and the relation to offspring cocaine responsiveness.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Article
- Neonatal mice exposed to a high-fat dietProceedings. Biological sciences · 2018Article
- Indirect ecological effects interact with community genetic effects in a host-parasite system and dramatically reduce parasite burden.Proceedings. Biological sciences · 2018Article
- Post-genomic behavioral genetics: From revolution to routine.Genes, brain, and behavior · 2018Review
- Born to Cry: A Genetic Dissection of Infant Vocalization.Frontiers in behavioral neuroscience · 2018Article
- Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.Nature communications · 2017Article
- Offspring genes indirectly influence sibling and maternal behavioural strategies over resource share.Proceedings. Biological sciences · 2017Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conflict over parental investment between parent and offspring is predicted to lead to selection on genes expressed in offspring for traits influencing maternal investment, and on parentally expressed genes affecting offspring behaviour. However, the specific genetic variants that indirectly modify maternal or offspring behaviour remain largely unknown. Using a cross-fostered population of mice, we map maternal behaviour in genetically uniform mothers as a function of genetic variation in offspring and identify loci on offspring chromosomes 5 and 7 that modify maternal behaviour. Conversely, we found that genetic variation among mothers influences offspring development, independent of offspring genotype. Offspring solicitation and maternal behaviour show signs of coadaptation as they are negatively correlated between mothers and their biological offspring, which may be linked to costs of increased solicitation on growth found in our study. Overall, our results show levels of parental provisioning and offspring solicitation are unique to specific genotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.