ArticleeLife2015
Long-distance communication by specialized cellular projections during pigment pattern development and evolution.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed.
- Regulation and function of specialized membrane protrusions in intercellular communication.Nature reviews. Molecular cell biology · 2026Review
- Review
- Rapid and repeated evolution of pigmentation patterns in reef fishes.BMC biology · 2026Article
- CD44 facilitates adhesive interactions in airineme-mediated intercellular signaling.bioRxiv : the preprint server for biology · 2025Article
- Article
- Making cells inter-connected for signaling communication: a developmental view of cytonemes.Cell communication and signaling : CCS · 2025Review
- CD44 facilitates adhesive interactions in airineme-mediated intercellular signaling.Frontiers in cell and developmental biology · 2025Article
- Experimentally Manipulating the Thyroid Hormone Axis in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.Developmental biology · 2024Article
- Genome-Wide Profiling of Cis-regulatory Elements in Mammalian Skin.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A macrophage subpopulation promotes airineme-mediated intercellular communication in a matrix metalloproteinase-9 dependent manner.Cell reports · 2023Article
- Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.bioRxiv : the preprint server for biology · 2023Article
- Review
- Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction.Nature communications · 2022Article
- Article
- Regulatory mechanisms of cytoneme-based morphogen transport.Cellular and molecular life sciences : CMLS · 2022Review
- Studies of Turing pattern formation in zebrafish skin.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Review
- Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects.Biology open · 2021Article
- Developmental genetics of color pattern establishment in cats.Nature communications · 2021Article
- Improving the understanding of cytoneme-mediated morphogen gradients by in silico modeling.PLoS computational biology · 2021Article
4 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
Abstract
Changes in gene activity are essential for evolutionary diversification. Yet, elucidating the cellular behaviors that underlie modifications to adult form remains a profound challenge. We use neural crest-derived adult pigmentation of zebrafish and pearl danio to uncover cellular bases for alternative pattern states. We show that stripes in zebrafish require a novel class of thin, fast cellular projection to promote Delta-Notch signaling over long distances from cells of the xanthophore lineage to melanophores. Projections depended on microfilaments and microtubules, exhibited meandering trajectories, and stabilized on target cells to which they delivered membraneous vesicles. By contrast, the uniformly patterned pearl danio lacked such projections, concomitant with Colony stimulating factor 1-dependent changes in xanthophore differentiation that likely curtail signaling available to melanophores. Our study reveals a novel mechanism of cellular communication, roles for differentiation state heterogeneity in pigment cell interactions, and an unanticipated morphogenetic behavior contributing to a striking difference in adult form.
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