Evidence map›Paper›PMID 26701888›Full record

ArticleOncotarget2016

Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells.

Ahmed Abdelbaset-Ismail, Sylwia Borkowska, Anna Janowska-Wieczorek, Torsten Tonn, Cesar Rodriguez, Marcin Moniuszko, Lukasz Bolkun, Janusz Koloczko, Andrzej Eljaszewicz, Janina Ratajczak and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  9. Androgen Therapy for Acute Myeloid and Hairy Cell Leukemia.Current treatment options in oncology · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Ahmed Abdelbaset-IsmailStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, KY, USA.
Sylwia BorkowskaPomeranian Medical University, Szczecin, Poland.
Anna Janowska-WieczorekDepartment of Hematology, University of Alberta, Edmonton, Canada.
Torsten TonnTransfusion Medicine, Medical Faculty Carl Gustav Carus - Technische Universtität Dresden, German Red Cross Blood Donation Service North East, Dresden, Germany.
Cesar RodriguezStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, KY, USA.
Marcin MoniuszkoDepartment of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.
Lukasz BolkunDepartment of Hematology, Medical University of Bialystok, Bialystok, Poland.
Janusz KoloczkoDepartment of Hematology, Medical University of Bialystok, Bialystok, Poland.
Andrzej EljaszewiczDepartment of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Bialystok, Poland.
Janina RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, KY, USA.
Mariusz Z RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, KY, USA.
Magda KuciaStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, KY, USA.
Medical University of Białystok · PLUniversity of Louisville · USJames Graham Brown Foundation · USGerman Red Cross · DEPomeranian Medical University · PLUniversity of Alberta · CA

Funding

Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
BIOACTIVE LIPIDS IN STEM CELL HOMING AND MOBILIZATIONR01HL112788 · NHLBI · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL112788NHLBI NIH HHS R01HL112788NIDDK NIH HHS 2R01DK074720NIDDK NIH HHS R01 DK074720
6 · The paper itself

Abstract

We recently reported that normal hematopoietic stem cells express functional pituitary sex hormone (SexH) receptors. Here we report for the first time that pituitary-secreted gonadotrophins stimulate migration, adhesion, and proliferation of several human myeloid and lymphoid leukemia cell lines. Similar effects were observed after stimulation of human leukemic cell lines by gonadal SexHs. This effect seems to be direct, as the SexH receptors expressed by leukemic cells responded to stimulation by phosphorylation of MAPKp42/44 and AKTser473. Furthermore, in parallel studies we confirmed that human primary patient-derived AML and CML blasts also express several functional SexH receptors. These results shed more light on the potential role of SexHs in leukemogenesis and, in addition, provide further evidence suggesting a developmental link between hematopoiesis and the germline.

Indexed as

Cell AdhesionCell Line, TumorCell MovementCell ProliferationFollicle Stimulating HormoneGonadotropins, PituitaryHumansJurkat CellsLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteLuteinizing HormoneMitogen-Activated Protein KinasesMyeloid CellsPhosphorylationProto-Oncogene Proteins c-aktReceptors, Pituitary HormoneFollicle Stimulating HormoneGonadotropins, PituitaryLuteinizing HormoneMitogen-Activated Protein KinasesProto-Oncogene Proteins c-aktReceptors, Pituitary HormoneFSHgerm lineleukemiaLHlymphoma

Identifiers

PMID26701888
PMCPMC4823088
OpenAlexW2276714563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.