Evidence map›Paper›PMID 26701877›Full record

ArticleGut2016

Evolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagus.

Danielle L Lavery, Pierre Martinez, Laura J Gay, Biancastella Cereser, Marco R Novelli, Manuel Rodriguez-Justo, Sybren L Meijer, Trevor A Graham, Stuart A C McDonald, Nicholas A Wright and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Histology of Barrett's Metaplasia: Do Goblet Cells Matter?Digestive diseases and sciences · 2018
    Review
  13. Article
  14. Review
  15. The metaplastic mosaic of Barrett's oesophagus.Virchows Archiv : an international journal of pathology · 2018
    Review
  16. Review
  17. Article
  18. The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models.Cellular and molecular gastroenterology and hepatology · 2017
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Danielle L LaveryBarts Cancer Institute, Queen Mary University of London, London, UK.
Pierre MartinezBarts Cancer Institute, Queen Mary University of London, London, UK.
Laura J GayBarts Cancer Institute, Queen Mary University of London, London, UK.
Biancastella CereserBarts Cancer Institute, Queen Mary University of London, London, UK.
Marco R NovelliDepartment of Pathology, University College London, London, UK.
Manuel Rodriguez-JustoDepartment of Pathology, University College London, London, UK.
Sybren L MeijerDepartment of Pathology, Academic Medical Centre, Amsterdam, The Netherlands.
Trevor A GrahamBarts Cancer Institute, Queen Mary University of London, London, UK.
Stuart A C McDonaldBarts Cancer Institute, Queen Mary University of London, London, UK.
Nicholas A WrightBarts Cancer Institute, Queen Mary University of London, London, UK.
Marnix JansenBarts Cancer Institute, Queen Mary University of London, London, UK Department of Pathology, Academic Medical Centre, Amsterdam, The Netherlands.
Queen Mary University of London · GBUniversity College London · GBAcademic Medical Center · NL

Funding

Cancer Research UK 14895Cancer Research UK A14895
6 · The paper itself

Abstract

objectiveBarrett's oesophagus commonly presents as a patchwork of columnar metaplasia with and without goblet cells in the distal oesophagus. The presence of metaplastic columnar epithelium with goblet cells on oesophageal biopsy is a marker of cancer progression risk, but it is unclear whether clonal expansion and progression in Barrett's oesophagus is exclusive to columnar epithelium with goblet cells.

designWe developed a novel method to trace the clonal ancestry of an oesophageal adenocarcinoma across an entire Barrett's segment. Clonal expansions in Barrett's mucosa were identified using cytochrome c oxidase enzyme histochemistry. Somatic mutations were identified through mitochondrial DNA sequencing and single gland whole exome sequencing.

resultsBy tracing the clonal origin of an oesophageal adenocarcinoma across an entire Barrett's segment through a combination of histopathological spatial mapping and clonal ordering, we find that this cancer developed from a premalignant clonal expansion in non-dysplastic ('cardia-type') columnar metaplasia without goblet cells.

conclusionOur data demonstrate the premalignant potential of metaplastic columnar epithelium without goblet cells in the context of Barrett's oesophagus.

Indexed as

AdenocarcinomaBarrett EsophagusBiopsyElectron Transport Complex IVEpitheliumEsophageal NeoplasmsExomeFemaleGoblet CellsHumansMetaplasiaMiddle AgedMitochondriaMutationSequence Analysis, DNAElectron Transport Complex IVBARRETT'S CARCINOMABARRETT'S METAPLASIABARRETT'S OESOPHAGUS

Identifiers

PMID26701877
PMCPMC4893117
OpenAlexW2265516298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.