Evidence map›Paper›PMID 26701850›Full record

ArticleOncotarget2016

Genetic variants in ERBB4 is associated with chronic hepatitis B virus infection.

Yao Liu, Qun Zhou, Xiao-Shun He, Li-Ming Song, Lin Chen, Wei-Juan Jiao, Tong Shen, Su Yao, Hua Wu, Zhi-Bin Hu and 2 more

Open access · diamondAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Yao LiuDepartment of Pathology, Medical College of Soochow University, Suzhou 215123, People's Republic of China.
Qun ZhouDepartment of Pathology, Medical College of Soochow University, Suzhou 215123, People's Republic of China.
Xiao-Shun HeDepartment of Pathology, Medical College of Soochow University, Suzhou 215123, People's Republic of China.
Li-Ming SongDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China.
Lin ChenDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China.
Wei-Juan JiaoDepartment of Pathology, Medical College of Soochow University, Suzhou 215123, People's Republic of China.
Tong ShenDepartment of Pathology, Medical College of Soochow University, Suzhou 215123, People's Republic of China.
Su YaoDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China.
Hua WuDepartment of Pathology, Medical College of Soochow University, Suzhou 215123, People's Republic of China.
Zhi-Bin HuDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, People's Republic of China.
Tian-Ming GaoDepartment of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, People's Republic of China.
Jian-Ming LiDepartment of Pathology, Medical College of Soochow University, Suzhou 215123, People's Republic of China.
Soochow University · CNNanfang Hospital · CNSouthern Medical University · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of ERBB4 in liver disease has seldom been reported. This study aims to find genetic markers at ERBB4 for chronic hepatitis B virus (HBV) infection and determine the role of ERBB4 in liver injury.

methodsWe selected and genotyped three single nucleotide polymorphisms and one insertion/deletion (Ins/Del) at the 5' and 3' untranslated region (UTR) of ERBB4 in a case-control study including 1344 pairs of HBV carriers and HBV natural clearance subjects. The luciferase reporter system was applied to study the regulative role of Ins/Del on ERBB4. Further, ERBB4 knockout mice were used to study the role of ERBB4 in liver injury. Proteomic quantification was performed by HPLC-MS/MS analysis to identify liver protein profile change between liver-specific ERBB4 knockout and control mice.

resultsrs6147150 Ins/Del and rs1836724 T>C at the 3' UTR of ERBB4 were associated with reduced risk of chronic HBV infection (P = 0.002 and 0.004, respectively). Besides, the 12bp deletion at the 3' UTR increased ERBB4 expression due to lacking let-7c binding site. In addition, loss of ERBB4 led to more severe acute or chronic inflammation in mouse liver injury models. Further, quantitative proteomic analysis and data from the cancer genome atlas revealed that ACLY, an enzyme key for de novo lipogenesis, was negatively correlated with ERBB4.

conclusionsERBB4 plays protective role from liver injury and its 3'UTR genetic variants could be genetic markers for chronic HBV infection.

Indexed as

AnimalsCase-Control StudiesDisease Models, AnimalFollow-Up StudiesHeLa CellsHepatitis B, ChronicHepatitis B virusHep G2 CellsHumansInflammationLiver DiseasesMaleMiceMice, Inbred C57BLMice, KnockoutPolymorphism, Single NucleotideERBB4 protein, humanReceptor, ErbB-4ERBB4hepatitis B virusinflammationpolymorphism

Identifiers

PMID26701850
PMCPMC4826259
OpenAlexW2228024052

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.