ArticleCell metabolism2016
SerpinB1 Promotes Pancreatic β Cell Proliferation.
Abstract read
In one paragraph
Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Contribution of Liver and Pancreatic Islet Crosstalk to β-Cell Function/Dysfunction in the Presence of Fatty Liver.Frontiers in endocrinology · 2022Pooled it
- Transient receptor potential canonical (TRPC) channels in diabetes and associated complications.Channels (Austin, Tex.) · 2026Review
- mNature metabolism · 2026Article
- Liver-pancreas communication in disease and drug development.Acta pharmaceutica Sinica. B · 2026Review
- Genetic recording of pancreatic beta cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Endothelial Cell Secretome Alterations Induced by Inflammatory Stress.bioRxiv : the preprint server for biology · 2026Article
- Gene family-level endocrine compensation and metabolic reprogramming preserve growth homeostasis under sustained insulin-like peptide suppression inFrontiers in endocrinology · 2026Article
- Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Novel Role of Neutrophil Elastase in Podocyte Dysfunction Induced by High Glucose, PMA, and MDP.Journal of cellular physiology · 2025Article
- Genome-wide CRISPR Screen Identifies Sec31A as a Key Regulator of Alpha Cell Survival.Nature communications · 2025Article
- Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes.Cellular & molecular biology letters · 2025Review
- SIRT2 puts the brakes on human β cell proliferation: therapeutic opportunities and next challenges.The Journal of clinical investigation · 2025Article
- The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation.The Journal of clinical investigation · 2025Article
- Dynamic multi-omics profiling of islet and gut hormonal secretion and peripheral crosstalk in response to various nutrient loads.Cell reports. Medicine · 2025Article
- Drug-induced regeneration of pancreatic beta cells: An approach to cellular therapeutic targets.Cell regeneration (London, England) · 2025Review
- HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes.Cell metabolism · 2025Article
- Pancreatic exocrine damage induces beta cell stress in zebrafish larvae.Diabetologia · 2025Article
- Effect of lipotoxic hepatocyte-derived extracellular vesicles in pancreas inflammation: essential role of macrophage TLR4 in beta cell functionality.Diabetologia · 2025Article
- Mechanistic insights and approaches for beta cell regeneration.Nature chemical biology · 2025Review
- Colonic inflammation triggers β cell proliferation during obesity development via a liver-to-pancreas interorgan mechanism.JCI insight · 2025Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors.
Abdelfattah El OuaamariIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Ercument DiriceIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Nicholas GedeonIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Jiang HuIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Jian-Ying ZhouBiological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Jun ShirakawaIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Lifei HouProgram in Cellular and Molecular Medicine at Boston Children's Hospital, 3 Blackfan Circle, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA.
Jessica GoodmanProgram in Cellular and Molecular Medicine at Boston Children's Hospital, 3 Blackfan Circle, Boston, MA 02215, USA.
Christos KarampeliasDepartment of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3, 17177 Stockholm, Sweden.
Guifeng QiangDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
Jeremie BoucherSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Cardiovascular and Metabolic Diseases iMed, AstraZeneca R&D, 431 83 Mölndal, Sweden.
Rachael MartinezIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Marina A GritsenkoBiological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Dario F De JesusIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Sevim KahramanIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Shweta BhattIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA.
Richard D SmithBiological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Hans-Dietmar BeerUniversity Hospital Zurich, Department of Dermatology, 8006 Zurich, Switzerland.
Prapaporn JungtrakoonSection on Genetics and Epidemiology, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA.
Yanping GongProgram in Cellular and Molecular Medicine at Boston Children's Hospital, 3 Blackfan Circle, Boston, MA 02215, USA.
Allison B GoldfineSection on Clinical Research, Joslin Diabetes Center and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.
Chong Wee LiewDepartment of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA.
Alessandro DoriaSection on Genetics and Epidemiology, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA.
Olov AnderssonDepartment of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3, 17177 Stockholm, Sweden.
Wei-Jun QianBiological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Eileen Remold-O'DonnellProgram in Cellular and Molecular Medicine at Boston Children's Hospital, 3 Blackfan Circle, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02215, USA; Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02215, USA.
Rohit N KulkarniIslet Cell and Regenerative Medicine, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute, Boston, MA 02215, USA. Electronic address: rohit.kulkarni@joslin.harvard.edu.
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MEquipment Supplement Request for a Research Resource for Ultra-sensitive High Throughput ProteomicsP41GM103493 · NIGMS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2012 to 2022
$22.6MRole of IGF-1 and Insulin Receptors Beta-Cell SurvivalR01DK067536 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 2004 to 2026
$8.0MSearch for new MODY genes and molecular studies of their function in beta cellsR01DK055523 · NIDDK · JOSLIN DIABETES CENTER · PI DORIA, ALESSANDRO, KULKARNI, ROHIT N. · 1998 to 2014
$4.0MROLE OF PROTEASE IN INFECTION &INFLAMMATION OF COPDR01HL066548 · NHLBI · IMMUNE DISEASE INSTITUTE, INC. · PI REMOLD-O'DONNELL, EILEEN · 2000 to 2010
$3.7MRegulatory Networks and Biomarkers of Beta-cell Dysfunction and ApoptosisUC4DK104167 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI KULKARNI, ROHIT N., MATHEWS, CLAYTON E · 2014 to 2016
$2.7MRole of SerpinB1 in beta cell growthR01DK103215 · NIDDK · JOSLIN DIABETES CENTER · PI KULKARNI, ROHIT N. · 2014 to 2018
$2.6MProteomics Studies of Type 2 Diabetes Using Knockout Mouse ModelsR01DK074795 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2008 to 2012
$2.0MRole of the transcriptional coregulator, TRIP Br2, in adipocyte metabolismR00DK090210 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LIEW, CHONG WEE · 2012 to 2014
$724kRegulation of NETosis in antibacterial lung defenseR21AI103407 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI REMOLD-O'DONNELL, EILEEN · 2013 to 2014
$482kRole of the transcriptional coregulator, TRIP Br2, in adipocyte metabolismK99DK090210 · NIDDK · JOSLIN DIABETES CENTER · PI LIEW, CHONG WEE · 2010 to 2011
$179kNHLBI NIH HHS R01 HL066548NIAID NIH HHS R21 AI103407NIDDK NIH HHS K99 DK090210NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R00 DK090210NIDDK NIH HHS R01 DK055523NIDDK NIH HHS R01 DK067536NIDDK NIH HHS R01 DK 074795NIDDK NIH HHS R01 DK074795NIDDK NIH HHS R01 DK103215NIDDK NIH HHS R01 DK55523NIDDK NIH HHS R01 DK67536NIDDK NIH HHS UC4 DK104167NIGMS NIH HHS P41 GM103493
Abstract
Although compensatory islet hyperplasia in response to insulin resistance is a recognized feature in diabetes, the factor(s) that promote β cell proliferation have been elusive. We previously reported that the liver is a source for such factors in the liver insulin receptor knockout (LIRKO) mouse, an insulin resistance model that manifests islet hyperplasia. Using proteomics we show that serpinB1, a protease inhibitor, which is abundant in the hepatocyte secretome and sera derived from LIRKO mice, is the liver-derived secretory protein that regulates β cell proliferation in humans, mice, and zebrafish. Small-molecule compounds, that partially mimic serpinB1 effects of inhibiting elastase activity, enhanced proliferation of β cells, and mice lacking serpinB1 exhibit attenuated β cell compensation in response to insulin resistance. Finally, SerpinB1 treatment of islets modulated proteins in growth/survival pathways. Together, these data implicate serpinB1 as an endogenous protein that can potentially be harnessed to enhance functional β cell mass in patients with diabetes.
Indexed as
Cell ProliferationAnimalsCells, CulturedHumansInsulin ResistanceInsulin-Secreting CellsLiverMaleMice, Inbred C57BLMice, KnockoutReceptor, InsulinSerpinsSignal TransductionZebrafishReceptor, InsulinSerpinb1a protein, mouseSerpins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.