ArticleNeuroscience2016
Noise trauma induced plastic changes in brain regions outside the classical auditory pathway.
Article in Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Bidirectional associations between sensorineural hearing loss and depression and anxiety: a meta-analysis.Frontiers in public health · 2023Pooled it
- Complex multisource sound induces greater neurodegeneration in neonatal rat brain than single-source sound.Frontiers in systems neuroscience · 2026Article
- Foxg1 gene mutation impairs auditory cortex response and reduces sound tolerance.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Auditory decision-making deficits after permanent noise-induced hearing loss.Scientific reports · 2025Article
- Map plasticity following noise exposure in auditory cortex of rats: implications for disentangling neural correlates of tinnitus and hyperacusis.Frontiers in neuroscience · 2024Article
- Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice.Environmental health perspectives · 2023Article
- Tinnitus, sound intolerance, and mental health: the role of long-term occupational noise exposure.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Article
- Clinical and investigational tools for monitoring noise-induced hyperacusis.The Journal of the Acoustical Society of America · 2022Review
- Prenatal stress dysregulates resting-state functional connectivity and sensory motifs.Neurobiology of stress · 2021Article
- Environmental noise degrades hippocampus-related learning and memory.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Disrupted Amygdala Connectivity Is Associated With Elevated Anxiety in Sensorineural Hearing Loss.Frontiers in neuroscience · 2020Article
- Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma.Frontiers in neuroscience · 2020Article
- Noise-Induced loudness recruitment and hyperacusis: Insufficient central gain in auditory cortex and amygdala.Neuroscience · 2019Article
- Testing the Central Gain Model: Loudness Growth Correlates with Central Auditory Gain Enhancement in a Rodent Model of Hyperacusis.Neuroscience · 2019Article
- Auditory central gain compensates for changes in cochlear output after prolonged low-level noise exposure.Neuroscience letters · 2018Article
- Effect of Neuronal Excitability in Hippocampal CA1 Area on Auditory Pathway in a Rat Model of Tinnitus.Chinese medical journal · 2018Article
- Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.Brain structure & function · 2018Article
- Prolonged low-level noise-induced plasticity in the peripheral and central auditory system of rats.Neuroscience · 2017Article
- Noise-induced hearing loss induces loudness intolerance in a rat Active Sound Avoidance Paradigm (ASAP).Hearing research · 2017Article
- Hyperexcitability of inferior colliculus and acoustic startle reflex with age-related hearing loss.Hearing research · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The effects of intense noise exposure on the classical auditory pathway have been extensively investigated; however, little is known about the effects of noise-induced hearing loss on non-classical auditory areas in the brain such as the lateral amygdala (LA) and striatum (Str). To address this issue, we compared the noise-induced changes in spontaneous and tone-evoked responses from multiunit clusters (MUC) in the LA and Str with those seen in auditory cortex (AC) in rats. High-frequency octave band noise (10-20 kHz) and narrow band noise (16-20 kHz) induced permanent threshold shifts at high-frequencies within and above the noise band but not at low frequencies. While the noise trauma significantly elevated spontaneous discharge rate (SR) in the AC, SRs in the LA and Str were only slightly increased across all frequencies. The high-frequency noise trauma affected tone-evoked firing rates in frequency and time-dependent manner and the changes appeared to be related to the severity of noise trauma. In the LA, tone-evoked firing rates were reduced at the high-frequencies (trauma area) whereas firing rates were enhanced at the low-frequencies or at the edge-frequency dependent on severity of hearing loss at the high frequencies. The firing rate temporal profile changed from a broad plateau to one sharp, delayed peak. In the AC, tone-evoked firing rates were depressed at high frequencies and enhanced at the low frequencies while the firing rate temporal profiles became substantially broader. In contrast, firing rates in the Str were generally decreased and firing rate temporal profiles become more phasic and less prolonged. The altered firing rate and pattern at low frequencies induced by high-frequency hearing loss could have perceptual consequences. The tone-evoked hyperactivity in low-frequency MUC could manifest as hyperacusis whereas the discharge pattern changes could affect temporal resolution and integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.