Evidence map›Paper›PMID 26701274›Full record

ArticleJournal of oral microbiology2015

Salivary mucins in host defense and disease prevention.

Erica Shapiro Frenkel, Katharina Ribbeck

Open access · goldAbstract read
In one paragraph

Article in Journal of oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 197 citations in OpenAlex.

  1. Host interactomes ofMicrobiology spectrum · 2026
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  12. Immunological Status of Saliva in Children with Asthma by Disease Severity.International journal of clinical pediatric dentistry · 2025
    Article
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  19. Review
  20. Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Erica Shapiro FrenkelBiological Sciences in Dental Medicine, Harvard University, Cambridge, MA, USA.
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA; ribbeck@mit.edu.
Harvard University · USMassachusetts Institute of Technology · US

Funding

Mucin Glycans in the Regulation of Microbial VirulenceR01EB017755 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI RIBBECK, KATHARINA · 2013 to 2022
$3.6M
The Role of Salivary Mucin in Preventing Cariogenic Streptococcus Biofilm FormationF30DE024917 · NIDCR · HARVARD MEDICAL SCHOOL · PI FRENKEL, ERICA SHAPIRO · 2015 to 2018
$165k
NIBIB NIH HHS R01 EB017755NIDCR NIH HHS F30 DE024917
6 · The paper itself

Abstract

Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic properties, are critical components of the gel layer that protect against invading pathogens. Altered mucin production has been implicated in diseases such as ulcerative colitis, asthma, and cystic fibrosis, which highlights the importance of mucins in maintaining homeostasis. Different types of mucins exist throughout the body in various locations such as the gastrointestinal tract, lungs, and female genital tract, but this review will focus on mucins in the oral cavity. Salivary mucin structure, localization within the oral cavity, and defense mechanisms will be discussed. These concepts will then be applied to present what is known about the protective function of mucins in oral diseases such as HIV/AIDS, oral candidiasis, and dental caries.

Indexed as

MUC5BMUC7mucinoral healthsaliva

Identifiers

PMID26701274
PMCPMC4689954
OpenAlexW2202049815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.