Evidence map›Paper›PMID 26701216›Full record

GuidelineNature reviews. Cardiology2016

Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment.

Larissa Fabritz, Eduard Guasch, Charalambos Antoniades, Isabel Bardinet, Gerlinde Benninger, Tim R Betts, Eva Brand, Günter Breithardt, Gabriela Bucklar-Suchankova, A John Camm and 21 more

Registry-linked trialAbstract readPractice GuidelineReviewConsensus Statement
PubMed Publisher
In one paragraph

Guideline in Nature reviews. Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05351775 (Cardiovascular Research Consortium - a Randomized Prospective Trial to Assess Low Workload Concept for the Detection of Silent Atrial Fibrillation), which is not on this map. Cited by 74 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05351775 nacompletednot on this mapstarted 2022, after this paper: background citation

Cardiovascular Research Consortium - a Randomized Prospective Trial to Assess Low Workload Concept for the Detection of Silent Atrial Fibrillation (AF) and Atrial Fibrillation Burden in Patients At High Risk of AF and Stroke

TypeinterventionalSponsorUniversity of TurkuRan2022 to 2025Enrolled150ConditionsAtrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular DiseasesArmsSmartphone application, Bed sensor, Wrist-worn photoplethysmography (PPG) and accelerometer data logger., Patch-holter ECG
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. European Heart Rhythm Association (EHRA)/European Association of Cardiovascular Prevention and Rehabilitation (EACPR) position paper on how to prevent atrial fibrillation endorsed by the Heart Rhythm Society (HRS) and Asia Pacific Heart Rhythm Society (APHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2017
    Guideline
  4. Guideline
  5. Interactions of blood biomolecules with early rhythm control in atrial fibrillation patients: exploratory analysis of the EAST-AFNET 4 biomolecule study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Review
  12. A novel technique for vein of Marshall blood sampling and its application in assessing atrial remodeling in atrial fibrillation.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Observational
  17. Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  18. Article
  19. Observational
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Larissa FabritzInstitute of Cardiovascular Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Eduard GuaschHospital Clinic de Barcelona, Villarroel, 170, 08036 Barcelona, Spain.
Charalambos AntoniadesDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Isabel BardinetEuropean Society of Cardiology, 2035 Route des Colles, 06903 Sophia Antipolis, France.
Gerlinde BenningerAtrial Fibrillation Network (AFNET) Association, Mendelstraße 11, 48149 Munich, Germany.
Tim R BettsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Eva BrandInternal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Münster, Schlossplatz 2, 48149 Munich, Germany.
Günter BreithardtDepartment of Cardiovascular Medicine, Division of Rhythmology, University Hospital Münster, Schlossplatz 2, 48149 Munich, Germany.
Gabriela Bucklar-SuchankovaRoche Professional Diagnostics, Forrenstrasse 2, CH-6343 Rotkreuz, Switzerland.
A John CammCardiovascular Sciences Research Centre, St George's University of London, Cranmer Terrace, London SW17 0RE, UK.
David CartlidgeUK Health and Environmental Research Institute, Pera Technology, Nottingham Road, Melton Mowbray LE13 0PB, UK.
Barbara CasadeiDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
Winnie W L ChuaInstitute of Cardiovascular Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Harry J G M CrijnsCardiovascular Research Institute Maastricht (CARIM), 6229 ER Maastricht, Netherlands.
Jon DeeksDepartment of Public Health, School of Health and Population Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Stéphane HatemUPMC Université Paris, 4 Place Jussieu, 75005 Paris, France.
Françoise Hidden-LucetUPMC Université Paris, 4 Place Jussieu, 75005 Paris, France.
Stefan KääbUniversity Hospital Munich, Department of Medicine I, Ludwig-Maximilians University, Professor-Huber-Platz 2, 80539 Munich, Germany.
Nikos ManiadakisNational School of Public Health, Leof. Alexandras 196, Athens, Greece.
Stephan MartinEuropean Society of Cardiology, 2035 Route des Colles, 06903 Sophia Antipolis, France.
Lluis MontHospital Clinic de Barcelona, Villarroel, 170, 08036 Barcelona, Spain.
Holger ReineckeDivision of Vascular Medicine, Department of Cardiovascular Medicine, University Hospital of Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Munich, Germany.
Moritz F SinnerUniversity Hospital Munich, Department of Medicine I, Ludwig-Maximilians University, Professor-Huber-Platz 2, 80539 Munich, Germany.
Ulrich SchottenCardiovascular Research Institute Maastricht (CARIM), 6229 ER Maastricht, Netherlands.
Taunton SouthwoodSchool of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Monika StollCardiovascular Research Institute Maastricht (CARIM), 6229 ER Maastricht, Netherlands.
Panos VardasUniversity of Crete, Heraklion GR-71003, Greece.
Reza WakiliUniversity Hospital Munich, Department of Medicine I, Ludwig-Maximilians University, Professor-Huber-Platz 2, 80539 Munich, Germany.
Andy WestUK Health and Environmental Research Institute, Pera Technology, Nottingham Road, Melton Mowbray LE13 0PB, UK.
André ZieglerRoche Professional Diagnostics, Forrenstrasse 2, CH-6343 Rotkreuz, Switzerland.
Paulus KirchhofInstitute of Cardiovascular Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

Funding

British Heart Foundation FS/11/66/28855British Heart Foundation RG/11/15/29375
6 · The paper itself

Abstract

Despite remarkable advances in antiarrhythmic drugs, ablation procedures, and stroke-prevention strategies, atrial fibrillation (AF) remains an important cause of death and disability in middle-aged and elderly individuals. Unstructured management of patients with AF sharply contrasts with our detailed, although incomplete, knowledge of the mechanisms that cause AF and its complications. Altered calcium homeostasis, atrial fibrosis and ageing, ion-channel dysfunction, autonomic imbalance, fat-cell infiltration, and oxidative stress, in addition to a susceptible genetic background, contribute to the promotion, maintenance, and progression of AF. However, clinical management of patients with AF is currently guided by stroke risk parameters, AF pattern, and symptoms. In response to this apparent disconnect between the known pathophysiology of AF and clinical management, we propose a roadmap to develop a set of clinical markers that reflect the major causes of AF in patients. Thereby, the insights into the mechanisms causing AF will be transformed into a format that can underpin future personalized strategies to prevent and treat AF, ultimately informing better patient care.

Indexed as

AnimalsAtrial FibrillationCardiologyConsensusHumansPrecision MedicinePredictive Value of TestsPreventive Health ServicesRisk AssessmentRisk FactorsTreatment Outcome

Identifiers

PMID26701216

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.