ArticlePloS one2015
Quantifying the Interactions between Maternal and Fetal Heart Rates by Transfer Entropy.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Article
- Transformer-based deep learning for estimating bidirectional maternal-fetal cardiac coupling.Frontiers in medical technology · 2026Article
- A method for dyadic cardiac rhythmicity analysis: Preliminary evidence on bilateral interactions in fetal-maternal cardiac dynamics.Experimental physiology · 2025Article
- Fetal ECG-based analysis reveals the impact of fetal movements and maternal respiration on maternal-fetal heart rate synchronization.PloS one · 2024Article
- Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review.PloS one · 2023Article
- Investigating the effect of cholinergic and adrenergic blocking agents on maternal-fetal heart rates and their interactions in mice fetuses.Biology open · 2022Article
- Correlation between maternal and fetal heart rate increases with fetal mouse age in typical development and is disturbed in autism mouse model treated with valproic acid.Frontiers in psychiatry · 2022Article
- Similarities between maternal and fetal RR interval tachograms and their association with fetal development.Frontiers in physiology · 2022Article
- Deep learning identifies cardiac coupling between mother and fetus during gestation.Frontiers in cardiovascular medicine · 2022Article
- Interpersonal Physiological Synchrony for Detecting Moments of Connection in Persons With Dementia: A Pilot Study.Frontiers in psychology · 2021Article
- Cardiac interaction between mother and infant: enhancement of heart rate variability.Scientific reports · 2019Article
- The Interaction Analysis between the Sympathetic and Parasympathetic Systems in CHF by Using Transfer Entropy Method.Entropy (Basel, Switzerland) · 2018Article
- Cardiotocography and beyond: a review of one-dimensional Doppler ultrasound application in fetal monitoring.Physiological measurement · 2018Review
- Coupling Analysis of Fetal and Maternal Heart Rates via Transfer Entropy Using Magnetocardiography.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2018Article
- Article
- Use of radiotelemetry to assess perinatal cardiac function in the ovine fetus and newborn.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Dependence of nighttime sleep duration in one-month-old infants on alterations in natural and artificial photoperiod.Scientific reports · 2017Article
- Fetal Cardiac Doppler Signal Processing Techniques: Challenges and Future Research Directions.Frontiers in bioengineering and biotechnology · 2017Review
- Assessment of Fetal Development Using Cardiac Valve Intervals.Frontiers in physiology · 2017Article
- Circadian changes and sex-related differences in fetal heart rate parameters.Maternal health, neonatology and perinatology · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence of the short term relationship between maternal and fetal heart rates has been found in previous studies. However there is still limited knowledge about underlying mechanisms and patterns of the coupling throughout gestation. In this study, Transfer Entropy (TE) was used to quantify directed interactions between maternal and fetal heart rates at various time delays and gestational ages. Experimental results using maternal and fetal electrocardiograms showed significant coupling for 63 out of 65 fetuses, by statistically validating against surrogate pairs. Analysis of TE showed a decrease in transfer of information from fetus to the mother with gestational age, alongside the maturation of the fetus. On the other hand, maternal to fetal TE was significantly greater in mid (26-31 weeks) and late (32-41 weeks) gestation compared to early (16-25 weeks) gestation (Mann Whitney Wilcoxon (MWW) p<0.05). TE further increased from mid to late, for the fetuses with RMSSD of fetal heart rate being larger than 4 msec in the late gestation. This difference was not observed for the fetuses with smaller RMSSD, which could be associated with the quiet sleep state. Delay in the information transfer from mother to fetus significantly decreased (p = 0.03) from mid to late gestation, implying a decrease in fetal response time. These changes occur concomitant with the maturation of the fetal sensory and autonomic nervous systems with advancing gestational age. The effect of maternal respiratory rate derived from maternal ECG was also investigated and no significant relationship was found between breathing rate and TE at any lag. In conclusion, the application of TE with delays revealed detailed information on the fetal-maternal heart rate coupling strength and latency throughout gestation, which could provide novel clinical markers of fetal development and well-being.
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