ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2016
Epidemiology and characteristics of the dengue outbreak in Guangdong, Southern China, in 2014.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- A global dataset of publicly available dengue case count data.Scientific data · 2024Article
- Advancing knowledge of One Health in China: lessons for One Health from China's dengue control and prevention programs.Science in One Health · 2024Review
- Genetic structure of Aedes albopictus (Diptera: Culicidae) populations in China and relationship with the knockdown resistance mutations.Infectious diseases of poverty · 2023Article
- Epidemiological Characteristics and the Dynamic Transmission Model of Dengue Fever in Zhanjiang City, Guangdong Province in 2018.Tropical medicine and infectious disease · 2022Article
- Dengue virus in humans and mosquitoes and their molecular characteristics in northeastern Thailand 2016-2018.PloS one · 2021Article
- Determination of Factors Affecting Dengue Occurrence in Representative Areas of China: A Principal Component Regression Analysis.Frontiers in public health · 2020Article
- Epidemiological and Evolutionary Analysis of Dengue-1 Virus Detected in Guangdong during 2014: Recycling of Old and Formation of New Lineages.The American journal of tropical medicine and hygiene · 2019Article
- Evidence for multiple-insecticide resistance in urban Aedes albopictus populations in southern China.Parasites & vectors · 2018Article
- Serum Cytokine Profiles in Patients with Dengue Fever at the Acute Infection Phase.Disease markers · 2018Article
- The interplay of climate, intervention and imported cases as determinants of the 2014 dengue outbreak in Guangzhou.PLoS neglected tropical diseases · 2017Article
- Effective Protection Induced by a Monovalent DNA Vaccine against Dengue Virus (DV) Serotype 1 and a Bivalent DNA Vaccine against DV1 and DV2 in Mice.Frontiers in cellular and infection microbiology · 2017Article
- First identification of kdr allele F1534S in VGSC gene and its association with resistance to pyrethroid insecticides in Aedes albopictus populations from Haikou City, Hainan Island, China.Infectious diseases of poverty · 2016Article
- Epidemiological and molecular characterization of dengue viruses imported into Guangzhou during 2009-2013.SpringerPlus · 2016Article
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37 authors at 19 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Dengue is a rapidly spreading mosquito-borne disease caused by the dengue virus (DENV) and has emerged as a severe public health problem around the world. Guangdong, one of the southern Chinese provinces, experienced a serious outbreak of dengue in 2014, which was believed to be the worst dengue epidemic in China over the last 20 years. To better understand the epidemic, we collected the epidemiological data of the outbreak and analyzed 14,594 clinically suspected dengue patients from 25 hospitals in Guangdong. Dengue cases were then laboratory-confirmed by the detection of DENV non-structural protein 1 (NS1) antigen and/or DENV RNA. Afterwards, clinical manifestations of dengue patients were analyzed and 93 laboratory-positive serum specimens were chosen for the DENV serotyping and molecular analysis. Our data showed that the 2014 dengue outbreak in Guangdong had spread to 20 cities and more than 45 thousand people suffered from dengue fever. Of 14,594 participants, 11,387 were definitively diagnosed. Most manifested with a typical non-severe clinical course, and 1.96 % developed to severe dengue. The strains isolated successfully from the serum samples were identified as DENV-1. Genetic analyses revealed that the strains were classified into genotypes I and V of DENV-1, and the dengue epidemic of Guangdong in 2014 was caused by indigenous cases and imported cases from the neighboring Southeast Asian countries of Malaysia and Singapore. Overall, our study is informative and significant to the 2014 dengue outbreak in Guangdong and will provide crucial implications for dengue prevention and control in China and elsewhere.
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