ArticleReproduction (Cambridge, England)2016
The effects of voluntary exercise on oocyte quality in a diet-induced obese murine model.
Article in Reproduction (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Metabolic regulation of oocyte maturation and early embryo development in mammals.Life metabolism · 2026Review
- The effects of physical activity on female fertility: a narrative review.Journal of assisted reproduction and genetics · 2026Review
- Regular parental pre-mating exercise reduces offspring white adiposity and is associated with hypothalamic neurodevelopmental changes during lactation.Molecular metabolism · 2026Article
- Impact of Physical Activity on Ovarian Response: A Prospective Study Among In Vitro Fertilization Patients.Cureus · 2025Article
- Diet-Induced Obesity Alters Granulosa Cell Transcriptome and Ovarian Immune Environment in Mice.Life (Basel, Switzerland) · 2025Article
- Maternal high-fat high-sugar diet impairs bone quality and strength but not cartilage in aging mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Preconception Diet Interventions in Obese Outbred Mice and the Impact on Female Offspring Metabolic Health and Oocyte Quality.International journal of molecular sciences · 2024Article
- Article
- The impact of a maternal and offspring obesogenic diet on daughter's oocyte mitochondrial ultrastructure and bioenergetic responses. Insights from an outbred mouse model.Frontiers in physiology · 2023Article
- High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models.Nutrients · 2022Review
- Programming by maternal obesity: a pathway to poor cardiometabolic health in the offspring.The Proceedings of the Nutrition Society · 2022Review
- Effect of a dietary and exercise intervention in women with overweight and obesity undergoing fertility treatments: protocol for a randomized controlled trial.BMC nutrition · 2021Article
- The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function.Antioxidants (Basel, Switzerland) · 2021Review
- Lifestyle intervention prior to IVF does not improve embryo utilization rate and cumulative live birth rate in women with obesity: a nested cohort study.Human reproduction open · 2021Article
- Differential effects of high fat diet-induced obesity on oocyte mitochondrial functions in inbred and outbred mice.Scientific reports · 2020Article
- Metabolomic alternations of follicular fluid of obese women undergoing in-vitro fertilization treatment.Scientific reports · 2020Article
- Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Sport, doping and female fertility.Reproductive biology and endocrinology : RB&E · 2018Review
- Impact of exercise on oocyte quality in the POLG mitochondrial DNA mutator mouse.Reproduction (Cambridge, England) · 2018Article
- Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse.Biology of reproduction · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Obesity negatively affects many aspects of the human body including reproductive function. In females, the root of the decline in fertility is linked to problems in the oocyte. Problems seen in oocytes that positively correlate with increasing BMI include changes to the metabolism, lipid accumulation, meiosis, and metaphase II (MII) spindle structure. Studies in mice indicate that dietary interventions fail to reverse these problems. How exercise affects the oocytes has not been addressed. Therefore, we hypothesized an exercise intervention would improve oocyte quality. Here we show that in a mouse model of an exercise, intervention can improve lipid metabolism in germinal vesicle (GV) stage oocytes. Oocytes significantly increased activity and transcription of the β-oxidation enzyme hydroxyacyl-coenzyme A dehydrogenase in response to exercise training only if the mice had been fed a high-fat diet (HFD). An exercise intervention also reversed the lipid accumulation seen in GV stage oocytes of HFD females. However, delays in meiosis and disorganized MII spindles remained present. Therefore, exercise is able to improve, but not reverse, damage imparted on oocytes as a result of an HFD and obesity. By utilizing an exercise intervention on an HFD, we determined only lipid content, and lipid metabolism is changed in GV oocytes. Moving forward, interventions to improve oocyte quality may need to be more targeted to the oocyte specifically. Because of the HFD-induced deficiency in β-oxidation, dietary supplementation with substrates to improve lipid utilization may be more beneficial.
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