ArticleFamilial cancer2016
Recurrent candidiasis and early-onset gastric cancer in a patient with a genetically defined partial MYD88 defect.
Article in Familial cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Worldwide trend in research onFrontiers in microbiology · 2024Pooled it
- Case Report: Novel variants in theFrontiers in immunology · 2025Article
- GRB7 plays a promoting role in the progression of gastric cancer.BMC cancer · 2023Article
- A mosaic PIK3CA variant in a young adult with diffuse gastric cancer: case report.European journal of human genetics : EJHG · 2021Article
- Hydrogen inhibits the proliferation and migration of gastric cancer cells by modulating lncRNA MALAT1/miR-124-3p/EZH2 axis.Cancer cell international · 2021Article
- Multigene Panel Testing Increases the Number of Loci Associated with Gastric Cancer Predisposition.Cancers · 2019Article
- Role of germline aberrations affectingJournal of medical genetics · 2018Article
- Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity.International journal of molecular sciences · 2018Review
- Unraveling genetic predisposition to familial or early onset gastric cancer using germline whole-exome sequencing.European journal of human genetics : EJHG · 2017Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer is caused by both genetic and environmental factors. A woman who suffered from recurrent candidiasis throughout her life developed diffuse-type gastric cancer at the age of 23 years. Using whole-exome sequencing we identified a germline homozygous missense variant in MYD88. Immunological assays on peripheral blood mononuclear cells revealed an impaired immune response upon stimulation with Candida albicans, characterized by a defective production of the cytokine interleukin-17. Our data suggest that a genetic defect in MYD88 results in an impaired immune response and may increase gastric cancer risk.
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Registered trials
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