ArticleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2017
Seizing Control: From Current Treatments to Optogenetic Interventions in Epilepsy.
Article in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Suppression of epileptic seizures by transcranial activation of KNature communications · 2025Article
- Neurophotonic methods in approach to in vivo animal epileptic models: Advantages and limitations.Epilepsia · 2024Review
- Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures.Brain : a journal of neurology · 2023Article
- Photoelectrochemistry and Drift-Diffusion Simulations in a Polythiophene Film Interfaced with an Electrolyte.ACS applied materials & interfaces · 2021Article
- Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures.Brain : a journal of neurology · 2020Review
- The effect of external voltage stimulation on absence seizures.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020Article
- Article
- Review
- Optogenetic Low-Frequency Stimulation of Specific Neuronal Populations Abates Ictogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- An Integrated Circuit for Simultaneous Extracellular Electrophysiology Recording and Optogenetic Neural Manipulation.IEEE transactions on bio-medical engineering · 2017Article
- Optogenetic activation of VGLUT2-expressing excitatory neurons blocks epileptic seizure-like activity in the mouse entorhinal cortex.Scientific reports · 2017Article
- Organization and control of epileptic circuits in temporal lobe epilepsy.Progress in brain research · 2016Review
- Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy.Progress in brain research · 2016Review
- Optogenetic Approaches for Controlling Seizure Activity.Brain stimulationReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The unpredictability and severity of seizures contribute to the debilitating nature of epilepsy. These factors also render the condition particularly challenging to treat, as an ideal treatment would need to detect and halt the pathological bursts of hyperactivity without disrupting normal brain activity. Optogenetic techniques offer promising tools to study and perhaps eventually treat this episodic disorder by controlling specific brain circuits in epileptic animals with great temporal precision. Here, we briefly review the current treatment options for patients with epilepsy. We then describe the many ways optogenetics has allowed us to untangle the microcircuits involved in seizure activity, and how it has, in some cases, changed our perception of previous theories of seizure generation. Control of seizures with light is no longer a dream, and has been achieved in numerous different animal models of epilepsy. Beyond its application as a seizure suppressor, we highlight another facet of optogenetics in epilepsy, namely the ability to create "on-demand" seizures, as a tool to systematically probe the dynamics of networks during seizure initiation and propagation. Finally, we look into the future to discuss the possibilities and challenges of translating optogenetic techniques to clinical use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.