Trial reportJournal of the American College of Cardiology2015
Complete Versus Lesion-Only Primary PCI: The Randomized Cardiovascular MR CvLPRIT Substudy.
Trial report in Journal of the American College of Cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Completeness, timing, and guidance of percutaneous coronary intervention for myocardial infarction and multivessel disease: a systematic review and network meta-analysis.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Pooled it
- Fractional flow reserve-guided complete vs. culprit-only revascularization in ST-elevation myocardial infarction patients with multivessel disease: a meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Cost-Effectiveness of Fractional Flow Reserve-Guided Treatment for Acute Myocardial Infarction and Multivessel Disease: A Prespecified Analysis of the FRAME-AMI Randomized Clinical Trial.JAMA network open · 2024Pooled it
- Timing of Complete Revascularization in Patients with STEMI and Multivessel Disease: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2023Pooled it
- Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease.The Cochrane database of systematic reviews · 2017Pooled it
- Impact of complete revascularisation in relation to left ventricular function in patients with ST-segment elevation myocardial infarction and multivessel disease: a post hoc analysis of the COMPLETE randomised trial.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Trial
- Drop-out from cardiovascular magnetic resonance in a randomized controlled trial of ST-elevation myocardial infarction does not cause selection bias on endpoints.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Trial
- Infarct size and left ventricular remodelling after preventive percutaneous coronary intervention.Heart (British Cardiac Society) · 2016Trial
- Infarct size following complete revascularization in patients presenting with STEMI: a comparison of immediate and staged in-hospital non-infarct related artery PCI subgroups in the CvLPRIT study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2016Trial
- Infarct Size Following Treatment With Second- Versus Third-Generation P2Y12 Antagonists in Patients With Multivessel Coronary Disease at ST-Segment Elevation Myocardial Infarction in the CvLPRIT Study.Journal of the American Heart Association · 2016Trial
- Cardiac MR Characterization of Infarct-Related and Remote Myocardial Injury in Multivessel Disease After Acute Myocardial Infarction.Journal of magnetic resonance imaging : JMRI · 2026Article
- Accuracy and prognostic value of arm-exercise stress echocardiography for coronary disease.The international journal of cardiovascular imaging · 2026Article
- Establishment and validation of an artificial intelligence-based system for identifying the culprit vessel in patients with ST-segment elevated myocardial infarction: the ALERT study.BMJ digital health & AI · 2025Article
- Complete Revascularisation Following Acute MI: A Contemporary Review.Interventional cardiology (London, England) · 2025Review
- A Meta-Analysis of Timing of Complete Revascularization in Patients with ST-Elevation Myocardial Infarction.Journal of clinical medicine · 2024Article
- CMR Mapping: The 4th-Era Revolution in Cardiac Imaging.Journal of clinical medicine · 2024Review
- Article
- Acute coronary syndromes.Lancet (London, England) · 2022Review
- CMR for myocardial characterization in ischemic heart disease: state-of-the-art and future developments.European radiology experimental · 2021Review
- Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management.European heart journal · 2020Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundComplete revascularization may improve outcomes compared with an infarct-related artery (IRA)-only strategy in patients being treated with primary percutaneous coronary intervention (PPCI) who have multivessel disease presenting with ST-segment elevation myocardial infarction (STEMI). However, there is concern that non-IRA PCI may cause additional non-IRA myocardial infarction (MI).
objectivesThis study sought to determine whether in-hospital complete revascularization was associated with increased total infarct size compared with an IRA-only strategy.
methodsThis multicenter prospective, randomized, open-label, blinded endpoint clinical trial evaluated STEMI patients with multivessel disease having PPCI within 12 h of symptom onset. Patients were randomized to either IRA-only PCI or complete in-hospital revascularization. Contrast-enhanced cardiovascular magnetic resonance (CMR) was performed following PPCI (median day 3) and stress CMR at 9 months. The pre-specified primary endpoint was infarct size on pre-discharge CMR. The study had 80% power to detect a 4% difference in infarct size with 100 patients per group.
resultsOf the 296 patients in the main trial, 205 participated in the CMR substudy, and 203 patients (98 complete revascularization and 105 IRA-only) completed the pre-discharge CMR. The groups were well-matched. Total infarct size (median, interquartile range) was similar to IRA-only revascularization: 13.5% (6.2% to 21.9%) versus complete revascularization, 12.6% (7.2% to 22.6%) of left ventricular mass, p = 0.57 (95% confidence interval for difference in geometric means 0.82 to 1.41). The complete revascularization group had an increase in non-IRA MI on the pre-discharge CMR (22 of 98 vs. 11 of 105, p = 0.02). There was no difference in total infarct size or ischemic burden between treatment groups at follow-up CMR.
conclusionsMultivessel PCI in the setting of STEMI leads to a small increase in CMR-detected non-IRA MI, but total infarct size was not significantly different from an IRA-only revascularization strategy. (Complete Versus Lesion-Only Primary PCI Pilot Study [CvLPRIT]; ISRCTN70913605).
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