ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2016
Intra-molecular triplet energy transfer is a general approach to improve organic fluorophore photostability.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Optimizing Effective Labeling Efficiency in MINFLUX 3D DNA-PAINT Microscopy by Maximizing Marker Detection Probability.ACS photonics · 2026Article
- Minimally Invasive DNA-Mediated Photostabilization for Extended Single-Molecule and Super-resolution Imaging.bioRxiv : the preprint server for biology · 2025Article
- Leveraging Baird aromaticity for advancement of bioimaging applications.Journal of physical organic chemistry · 2023Article
- Homolytic N-S Bond Cleavage in Vinyl Triflimides Enabled by Triplet-Triplet Energy Transfer.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Molecular Prosthetics for Long-Term Functional Imaging with Fluorescent Reporters.ACS central science · 2022Article
- Targetable Conformationally Restricted Cyanines Enable Photon-Count-Limited Applications*.Angewandte Chemie (International ed. in English) · 2021Article
- Characterization of Fluorescent Proteins with Intramolecular Photostabilization*.Chembiochem : a European journal of chemical biology · 2021Article
- Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Strategies to maximize performance in STimulated Emission Depletion (STED) nanoscopy of biological specimens.Methods (San Diego, Calif.) · 2020Review
- Approaches for measuring the dynamics of RNA-protein interactions.Wiley interdisciplinary reviews. RNA · 2020Review
- A new structure-activity relationship for cyanine dyes to improve photostability and fluorescence properties for live cell imaging.Chemical science · 2018Article
- Heavy carbon nanodots: a new phosphorescent carbon nanostructure.Physical chemistry chemical physics : PCCP · 2018Article
- Single-Molecule Monitoring of the Structural Switching Dynamics of Nucleic Acids through Controlling Fluorescence Blinking.Angewandte Chemie (International ed. in English) · 2017Article
- Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging.Chemical science · 2017Article
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8 authors.
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Abstract
Bright, long-lasting and non-phototoxic organic fluorophores are essential to the continued advancement of biological imaging. Traditional approaches towards achieving photostability, such as the removal of molecular oxygen and the use of small-molecule additives in solution, suffer from potentially toxic side effects, particularly in the context of living cells. The direct conjugation of small-molecule triplet state quenchers, such as cyclooctatetraene (COT), to organic fluorophores has the potential to bypass these issues by restoring reactive fluorophore triplet states to the ground state through intra-molecular triplet energy transfer. Such methods have enabled marked improvement in cyanine fluorophore photostability spanning the visible spectrum. However, the generality of this strategy to chemically and structurally diverse fluorophore species has yet to be examined. Here, we show that the proximal linkage of COT increases the photon yield of a diverse range of organic fluorophores widely used in biological imaging applications, demonstrating that the intra-molecular triplet energy transfer mechanism is a potentially general approach for improving organic fluorophore performance and photostability.
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