ArticleJournal of pediatric surgery2016
Necrotizing enterocolitis is associated with earlier achievement of enteral autonomy in children with short bowel syndrome.
Article in Journal of pediatric surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Quality of life after necrotizing enterocolitis: an integrative review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2024Pooled it
- Clinical outcomes in pediatric intestinal failure: a meta-analysis and meta-regression.The American journal of clinical nutrition · 2019Pooled it
- Improved enteral tolerance following step procedure: systematic literature review and meta-analysis.Pediatric surgery international · 2016Pooled it
- Chronic Intestinal Failure During the Neonatal Period Related to Height at Five Years of Age.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Surgical Interventions for NEC-An Overview.Children (Basel, Switzerland) · 2026Review
- Serial Transverse Enteroplasty and the Reestablishment of Enteral Autonomy Among the Adult Population: New Insights With Advanced Clinical Practice and Novel Outcome Predictive Model.Annals of surgery · 2026Article
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- The bowel loss was preserved with surgical intervention based on multi-item scoring in infants with necrotizing enterocolitis.Frontiers in surgery · 2026Article
- Current operative approaches for necrotizing enterocolitis.World journal of pediatric surgery · 2026Review
- Surgical and nutritional outcomes of extremely low birth weight infants with enterostomy: a single-center retrospective study in China.Pediatric surgery international · 2025Article
- Risks and benefits of probiotics for preterm neonates: threshold of comfort or fear?Pediatric research · 2025Article
- Do hematological biomarkers predict surgical necrotizing enterocolitis?Pediatric research · 2024Article
- From intestinal failure to transplantation: Review on the current need for transplant indications under multidisciplinary transplant programs worldwide.Pediatric transplantation · 2024Review
- A new classification for surgical NEC during exploratory laparotomy: introduction and reproducibility assessment.Pediatric surgery international · 2024Article
- Predictors of 1-year enteral autonomy in children with intestinal failure: A descriptive retrospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2023Article
- Disruption of Enterohepatic Circulation of Bile Acids Ameliorates Small Bowel Resection Associated Hepatic Injury.Journal of pediatric surgery · 2023Article
- Efficient achievement of enteral autonomy facilitates resolution of liver injury in necrotizing enterocolitis induced short bowel syndrome.Scientific reports · 2022Article
- Association of neutropenia at disease onset with severe surgical necrotizing enterocolitis and higher mortality: A retrospective study.Frontiers in surgery · 2022Article
- Real-world etiologies and treatments of pediatric short bowel syndrome in Japan.Pediatrics international : official journal of the Japan Pediatric Society · 2022Observational
- Multi-Center Analysis of Predictive Factors of Enteral Autonomy and Risk Factors of Complications of Pediatric Intestinal Failure in China.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
purposeNecrotizing enterocolitis (NEC) remains one of the most common underlying diagnoses of short bowel syndrome (SBS) in children. The relationship between the etiology of SBS and ultimate enteral autonomy has not been well studied. This investigation sought to evaluate the rate of achievement of enteral autonomy in SBS patients with and without NEC.
methodsFollowing IRB approval, 109 patients (2002-2014) at a multidisciplinary intestinal rehabilitation program were reviewed. The primary outcome evaluated was achievement of enteral autonomy (i.e. fully weaning from parenteral nutrition). Patient demographics, primary diagnosis, residual small bowel length, percent expected small bowel length, median serum citrulline level, number of abdominal operations, status of the ileocecal valve (ICV), presence of ileostomy, liver function tests, and treatment for bacterial overgrowth were recorded for each patient.
resultsMedian age at PN onset was 0 weeks [IQR 0-0]. Median residual small bowel length was 33.5 cm [IQR 20-70]. NEC was present in 37 of 109 (33.9%) of patients. 45 patients (41%) achieved enteral autonomy after a median PN duration of 15.3 [IQR 7.2-38.4]months. Overall, 64.9% of patients with NEC achieved enteral autonomy compared to 29.2% of patients with a different primary diagnosis (p=0.001, Fig. 1). Patients with NEC remained more likely than those without NEC to achieve enteral autonomy after two (45.5% vs. 12.0%) and four (35.7% vs. 6.3%) years on PN (Fig. 1). Logistic regression analysis demonstrated the following parameters as independent predictors of enteral autonomy: diagnosis of NEC (p<0.002), median serum citrulline level (p<0.02), absence of a jejunostomy or ileostomy (p=0.013), and percent expected small bowel length (p=0.005).
conclusionsChildren with SBS because of NEC have a significantly higher likelihood of fully weaning from parenteral nutrition compared to children with other causes of SBS. Additionally, patients with NEC may attain enteral autonomy even after long durations of parenteral support.
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