Evidence map›Paper›PMID 26700663›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

Integrative computational in-depth analysis of dysregulated miRNA-mRNA interactions in drug-resistant pediatric acute lymphoblastic leukemia cells: an attempt to obtain new potential gene-miRNA pathways involved in response to treatment.

Hamzeh Mesrian Tanha, Marjan Mojtabavi Naeini, Soheila Rahgozar, Alireza Moafi, Mohammad Amin Honardoost

Abstract read
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In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Pharmacogenetics of asparaginase in acute lymphoblastic leukemia.Cancer drug resistance (Alhambra, Calif.) · 2019
    Review
  10. Article
  11. MiRNA Dysregulation in Childhood Hematological Cancer.International journal of molecular sciences · 2018
    Review
  12. MicroRNAs as prognostic biomarker and relapse indicator in leukemia.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2017
    Review
  13. Article
  14. Functional SNP in stem of mir-146a affects Her2 status and breast cancer survival.Cancer biomarkers : section A of Disease markers · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hamzeh Mesrian TanhaDivision of Cell and Molecular Biology, Department of Biology, Faculty of Science, University of Isfahan, Hezar Jarib Street, 8174673441, Isfahan, Iran.
Marjan Mojtabavi NaeiniDivision of Genetics, Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
Soheila RahgozarDivision of Cell and Molecular Biology, Department of Biology, Faculty of Science, University of Isfahan, Hezar Jarib Street, 8174673441, Isfahan, Iran. rahgozar@sci.ui.ac.ir.
Alireza MoafiDepartment of Pediatric Hematology Oncology, Sayed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Mohammad Amin HonardoostDivision of Cell and Molecular Biology, Department of Biology, Faculty of Science, University of Isfahan, Hezar Jarib Street, 8174673441, Isfahan, Iran.
University of Isfahan · IRIsfahan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lymphoblastic leukemia (ALL) is the major neoplasia type among children. Despite the tremendous success of current treatment strategies, drug resistance still remains a major cause of chemotherapy failure and relapse in pediatric patients. Overwhelming evidence illustrates that microRNAs (miRNAs) act as post-transcriptional regulators of drug-resistance-related genes. The current study was aimed at how dysregulated miRNA-mRNA-signaling pathway interaction networks mediate resistance to four commonly used chemotherapy agents in pediatric ALL, including asparaginase, daunorubicin, prednisolone, and vincristine. Using public expression microarray datasets, a holistic in silico approach was utilized to investigate candidate drug resistance miRNA-mRNA-signaling pathway interaction networks in pediatric ALL. Our systems biology approach nominated significant drug resistance and cross-resistance miRNAs, mRNAs, and cell signaling pathways based on anti-correlative relationship between miRNA and mRNA expression pattern. To sum up, our systemic analysis disclosed either a new potential role of miRNAs, or a possible mechanism of cellular drug resistance, in chemotherapy resistance of pediatric ALL. The current study may shed light on predicting drug response and overcoming drug resistance in childhood ALL for subsequent generations of chemotherapies.

Indexed as

Antineoplastic AgentsChildChild, PreschoolDrug Resistance, NeoplasmGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansMicroRNAsPrecursor Cell Lymphoblastic Leukemia-LymphomaRNA, MessengerSignal TransductionAntineoplastic AgentsMicroRNAsRNA, MessengerAcute lymphoblastic leukemiaDrug resistancemiRNASignaling pathwayTherapeutic targets

Identifiers

PMID26700663
OpenAlexW2235417995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.