Evidence map›Paper›PMID 26700184›Full record

Trial reportPloS one2015

Stress-Induced In Vivo Recruitment of Human Cytotoxic Natural Killer Cells Favors Subsets with Distinct Receptor Profiles and Associates with Increased Epinephrine Levels.

Marc B Bigler, Simon B Egli, Cédric M Hysek, Gideon Hoenger, Laurent Schmied, Fabian S Baldin, Florian A Marquardsen, Mike Recher, Matthias E Liechti, Christoph Hess and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Marc B BiglerTranslational Immunology, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
Simon B EgliTranslational Immunology, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
Cédric M HysekClinical Pharmacology, Dep. of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Gideon HoengerImmunobiology Lab, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
Laurent SchmiedImmunotherapy Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Fabian S BaldinImmunodeficiency Lab, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
Florian A MarquardsenImmunodeficiency Lab, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
Mike RecherImmunodeficiency Lab, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
Matthias E LiechtiClinical Pharmacology, Dep. of Internal Medicine, University Hospital Basel, Basel, Switzerland.
Christoph HessImmunobiology Lab, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
Christoph T BergerTranslational Immunology, Dep. of Biomedicine, University Hospital Basel, Basel, Switzerland.
University Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute stress drives a 'high-alert' response in the immune system. Psychoactive drugs induce distinct stress hormone profiles, offering a sought-after opportunity to dissect the in vivo immunological effects of acute stress in humans.

methods3,4-methylenedioxymethamphetamine (MDMA), methylphenidate (MPH), or both, were administered to healthy volunteers in a randomized, double-blind, placebo-controlled crossover-study. Lymphocyte subset frequencies, natural killer (NK) cell immune-phenotypes, and changes in effector function were assessed, and linked to stress hormone levels and expression of CD62L, CX3CR1, CD18, and stress hormone receptors on NK cells.

resultsMDMA/MPH > MDMA > MPH robustly induced an epinephrine-dominant stress response. Immunologically, rapid redistribution of peripheral blood lymphocyte-subsets towards phenotypically mature NK cells occurred. NK cytotoxicity was unaltered, but they expressed slightly reduced levels of the activating receptor NKG2D. Preferential circulation of mature NK cells was associated with high epinephrine receptor expression among this subset, as well as expression of integrin ligands previously linked to epinephrine-induced endothelial detachment.

conclusionThe acute epinephrine-induced stress response was characterized by rapid accumulation of mature and functional NK cells in the peripheral circulation. This is in line with studies using other acute stressors and supports the role of the acute stress response in rapidly mobilizing the innate immune system to counteract incoming threats.

Indexed as

Cells, CulturedCross-Over StudiesDouble-Blind MethodEpinephrineFemaleFlow CytometryHumansImmunophenotypingKiller Cells, NaturalLymphocyte SubsetsMaleReal-Time Polymerase Chain ReactionReceptors, Adrenergic, beta-2Receptors, GlucocorticoidReverse Transcriptase Polymerase Chain ReactionRNA, MessengerADRB2 protein, humanEpinephrineReceptors, Adrenergic, beta-2Receptors, GlucocorticoidRNA, Messenger

Identifiers

PMID26700184
PMCPMC4689586
OpenAlexW2202621783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.