Evidence map›Paper›PMID 26699796›Full record

ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2016

Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis.

Ilea T Swinehart, Stephen F Badylak

Abstract readReview
In one paragraph

Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 204 citations in OpenAlex.

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27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ilea T SwinehartMcGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania.
Stephen F BadylakMcGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania.
McGowan Institute for Regenerative Medicine · US

Funding

A Regenerative Medicine Approach for TMJ Meniscus RestorationR01DE022055 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALMARZA, ALEJANDRO JOSE, BADYLAK, STEPHEN F. · 2012 to 2015
$2.5M
NIDCR NIH HHS 1 R01 DE022055NIDCR NIH HHS R01 DE022055
6 · The paper itself

Abstract

During normal morphogenesis the extracellular matrix (ECM) influences cell motility, proliferation, apoptosis, and differentiation. Tissue engineers have attempted to harness the cell signaling potential of ECM to promote the functional reconstruction, if not regeneration, of injured or missing adult tissues that otherwise heal by the formation of scar tissue. ECM bioscaffolds, derived from decellularized tissues, have been used to promote the formation of site appropriate, functional tissues in many clinical applications including skeletal muscle, fibrocartilage, lower urinary tract, and esophageal reconstruction, among others. These scaffolds function by the release or exposure of growth factors and cryptic peptides, modulation of the immune response, and recruitment of progenitor cells. Herein, we describe this process of ECM induced constructive remodeling and examine similarities to normal tissue morphogenesis.

Indexed as

Tissue ScaffoldsAnimalsExtracellular MatrixFibrocartilageHumansMorphogenesisMuscle, Skeletalbioscaffoldextracellular matrixtissue remodeling

Identifiers

PMID26699796
PMCPMC4755921
OpenAlexW2236531859

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.