Evidence map›Paper›PMID 26699793›Full record

ArticleFood & nutrition research2015

Protective effect of soluble eggshell membrane protein hydrolysate on cardiac ischemia/reperfusion injury.

Tao Yang, Yan Li, Meihu Ma, Qinlu Lin, Shuguo Sun, Bin Zhang, Xi Feng, Junwen Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food & nutrition research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tao YangNational Engineering Laboratory of Rice and By-product Deep Processing, Central South University of Forestry and Technology, Changsha, People's Republic of China.
Yan LiNational Engineering Laboratory of Rice and By-product Deep Processing, Central South University of Forestry and Technology, Changsha, People's Republic of China.
Meihu MaNational R&D Center for Egg Processing, Huazhong Agricultural University, Wuhan, People's Republic of China.
Qinlu LinNational Engineering Laboratory of Rice and By-product Deep Processing, Central South University of Forestry and Technology, Changsha, People's Republic of China.
Shuguo SunNational Engineering Laboratory of Rice and By-product Deep Processing, Central South University of Forestry and Technology, Changsha, People's Republic of China.
Bin ZhangDepartment of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, People's Republic of China.
Xi FengDepartment of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, People's Republic of China.
Junwen LiuDepartment of Histology and Embryology, School of Basic Medical Sciences, Central South University, Changsha, People's Republic of China; liujunwen@csu.edu.cn.
Central South University · CNCentral South University of Forestry and Technology · CNHuazhong Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSoluble eggshell membrane protein (SEP) has been proved to hold the antioxidant activity. The functional role of SEP on cardioprotection was investigated in vivo and in vitro.

methodsRats and cardiomyocytes were pretreated with SP2, a hydrolysate attained from SEP, and then subjected to ischemia/reperfusion (I/R) or hypoxia/reoxygenation (H/R) and hydrogen peroxide, respectively. The measurement of myocardial infarct size, cell apoptosis assay, cell viability assay, and caspase activity assay were performed on rats and cardiomyocytes.

resultsThe results showed that the treatment of SP2 induced the resistance to I/R or H/R injury on rats and cardiomyocytes as indicated by decreased infarct size and decreased cellular apoptosis. The cardioprotective roles of SP2 were partly resulted from the downregulated expression and activity of caspase-3 in which the effect was similar to the caspase inhibitor, z-VAD-fmk, and could be rescued by caspase activator, PAC-1.

conclusionsThis investigation has demonstrated that SP2 attenuated the damage of I/R and H/R on rats and cardiomyocytes by the caspase-dependent pathway. This cardioprotective effect of SP2 suggested a novel therapeutic agent of SEP for ischemic-related heart diseases.

Indexed as

cardiomyocytescardioprotectioncaspaseischemia-reperfusion injurysoluble eggshell membrane protein

Identifiers

PMID26699793
PMCPMC4689127
OpenAlexW2201384706

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.