Evidence map›Paper›PMID 26699646›Full record

ReviewJournal of virology2015

European Academies Advise on Gain-of-Function Studies in Influenza Virus Research.

Robin Fears, Volker ter Meulen

Abstract readReview
In one paragraph

Review in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robin FearsBiosciences Programme, EASAC, German National Academy of Sciences, Halle (Saale), Germany Gain of Function Working Group, EASAC, German National Academy of Sciences, Halle (Saale), Germany.
Volker ter MeulenBiosciences Steering Panel, EASAC, German National Academy of Sciences, Halle (Saale), Germany Gain of Function Working Group, EASAC, German National Academy of Sciences, Halle (Saale), Germany Volker.termeulen@mail.uni-wuerzburg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gain-of-function (GoF) studies to understand factors affecting transmissibility of potentially pandemic pathogens are controversial. The European Academies Science Advisory Council (EASAC) recently published consensus recommendations relating to GoF research review and management on self-regulation and harmonization; bioethical considerations; benefit-risk assessment; biosafety, and biosecurity advisory options; and publication of sensitive information. A layered approach to integration of responsibilities must include conforming to the stringent rules and guidance already existing. Further commitment is essential to extend the debate on issues worldwide.

Indexed as

Disease Transmission, InfectiousAcademies and InstitutesBiomedical ResearchEuropeHumansInfluenza, HumanOrthomyxoviridaeOrthomyxoviridae InfectionsPandemicsVirologyVirulence

Identifiers

PMID26699646
PMCPMC4810713

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.