ArticleProceedings of the National Academy of Sciences of the United States of America2016
Functional hierarchy underlies preferential connectivity disturbances in schizophrenia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 165 citations in OpenAlex.
- Memantine Effects on Electroencephalographic Measures of Putative Excitatory/Inhibitory Balance in Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Trial
- Trial
- Multimodal neuroimaging reveals brain neurochemical disturbances associated with superoxide dismutase in first-episode drug-naïve schizophrenia.Translational psychiatry · 2026Article
- Human cortical dynamics reflect graded contributions of local geometry and network topography.Nature communications · 2025Article
- cuBNM: GPU-Accelerated Brain Network Modeling.bioRxiv : the preprint server for biology · 2025Article
- Reconfiguration of functional brain hierarchy in schizophrenia.Translational psychiatry · 2025Article
- Differential impacts of social isolation and enriched environment on multi-sensory brain-wide functionality and network segregation.Nature communications · 2025Article
- Using the excitation/inhibition ratio to optimize the classification of autism and schizophrenia.Translational psychiatry · 2025Article
- Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling.Science advances · 2025Article
- Reduced temporal variability of cortical excitation/inhibition ratio in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- A comparative machine learning study of schizophrenia biomarkers derived from functional connectivity.Scientific reports · 2025Article
- Disorder-specific neurodynamic features in schizophrenia inferred by neurodynamic embedded contrastive variational autoencoder model.Translational psychiatry · 2024Article
- Push-pull effects of basal ganglia network in Parkinson's disease inferred by functional MRI.NPJ Parkinson's disease · 2024Article
- Changes in the structure of spontaneous speech predict the disruption of hierarchical brain organization in first-episode psychosis.Human brain mapping · 2024Article
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
- Unveiling the therapeutic potential of IHMT-337 in glioma treatment: targeting the EZH2-SLC12A5 axis.Molecular medicine (Cambridge, Mass.) · 2024Article
- The multiscale topological organization of the functional brain network in adolescent PTSD.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Stronger tilt aftereffects in individuals diagnosed with schizophrenia spectrum disorders but not bipolar disorder.Schizophrenia research · 2024Article
- Measures of resting-state brain network segregation and integration vary in relation to data quantity: implications for within and between subject comparisons of functional brain network organization.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Measuring excitation-inhibition balance through spectral components of local field potentials.bioRxiv : the preprint server for biology · 2024Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Schizophrenia may involve an elevated excitation/inhibition (E/I) ratio in cortical microcircuits. It remains unknown how this regulatory disturbance maps onto neuroimaging findings. To address this issue, we implemented E/I perturbations within a neural model of large-scale functional connectivity, which predicted hyperconnectivity following E/I elevation. To test predictions, we examined resting-state functional MRI in 161 schizophrenia patients and 164 healthy subjects. As predicted, patients exhibited elevated functional connectivity that correlated with symptom levels, and was most prominent in association cortices, such as the fronto-parietal control network. This pattern was absent in patients with bipolar disorder (n = 73). To account for the pattern observed in schizophrenia, we integrated neurobiologically plausible, hierarchical differences in association vs. sensory recurrent neuronal dynamics into our model. This in silico architecture revealed preferential vulnerability of association networks to E/I imbalance, which we verified empirically. Reported effects implicate widespread microcircuit E/I imbalance as a parsimonious mechanism for emergent inhomogeneous dysconnectivity in schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.