ArticleEuropean radiology2016
Quantitative myocardial perfusion with stress dual-energy CT: iodine concentration differences between normal and ischemic or necrotic myocardium. Initial experience.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Predicting Chronic Myocardial Ischemia Using CCTA-Based Radiomics Machine Learning Nomogram.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Trial
- Spectral photon-counting CT in first-pass myocardial perfusion imaging for very high-risk patients: a comparison with dual-energy CT.European radiology experimental · 2025Article
- A case of bilateral adrenal infarction with preserved adrenal function diagnosed by dual-energy computed tomography.Radiology case reports · 2024Article
- Nomogram Based on Dual-Layer Spectral Detector CTA Parameter for the Prediction of Infarct Core in Patients with Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2023Article
- Iodine Images in Dual-energy CT: Detection of Hepatic Steatosis by Quantitative Iodine Concentration Values.Journal of digital imaging · 2022Article
- Dual-Energy CT of the Heart: A Review.Journal of imaging · 2022Review
- Effect of contrast material injection protocol on first-pass myocardial perfusion assessed by dual-energy dual-layer computed tomography.Quantitative imaging in medicine and surgery · 2022Article
- Iodine images in dual energy CT: A monocentric study benchmarking quantitative iodine concentration values of the healthy liver.PloS one · 2022Article
- Utility of dual-layer spectral-detector CT imaging for predicting pathological tumor stages and histologic grades of colorectal adenocarcinoma.Frontiers in oncology · 2022Article
- [Beyond Coronary CT Angiography: CT Fractional Flow Reserve and Perfusion].Taehan Yongsang Uihakhoe chi · 2022Review
- CT Assessment of Myocardial Perfusion and Fractional Flow Reserve in Coronary Artery Disease: A Review of Current Clinical Evidence and Recent Developments.Korean journal of radiology · 2021Review
- Quantitative benchmarking of iodine imaging for two CT spectral imaging technologies: a phantom study.European radiology experimental · 2021Article
- Role of DECT in coronary artery disease: a comparative study with ICA and SPECT.Diagnostic and interventional radiology (Ankara, Turkey) · 2020Article
- Functional cardiac CT-Going beyond Anatomical Evaluation of Coronary Artery Disease with Cine CT, CT-FFR, CT Perfusion and Machine Learning.The British journal of radiology · 2020Review
- Computed tomography for myocardial characterization in ischemic heart disease: a state-of-the-art review.European radiology experimental · 2020Review
- Computed tomographic evaluation of myocardial ischemia.Japanese journal of radiology · 2020Review
- Dynamic Quantitative Iodine Myocardial Perfusion Imaging with Dual-Layer CT using a Porcine Model.Scientific reports · 2019Article
- How accurate and precise are CT based measurements of iodine concentration? A comparison of the minimum detectable concentration difference among single source and dual source dual energy CT in a phantom study.European radiology · 2019Article
- Locally advanced gastric cancer: total iodine uptake to predict the response of primary lesion to neoadjuvant chemotherapy.Journal of cancer research and clinical oncology · 2018Article
- Cardiac CT: Technological Advances in Hardware, Software, and Machine Learning Applications.Current cardiovascular imaging reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine whether the quantification of iodine with stress dual-energy computed tomography (DECT-S) allows for the discrimination between a normal and an ischemic or necrotic myocardium using magnetic resonance (MR) as a reference.
methodsThis retrospective study was approved by the institutional review board, with waiver of informed consent. Thirty-six cardiac MR and DECT-S images from patients with suspected coronary artery disease were evaluated. Perfusion defects were visually determined, and myocardial iodine concentration was calculated by two observers using DECT colour-coded iodine maps. Iodine concentration differences were calculated using parametric tests. Receiver operating characteristic (ROC) curve analysis was conducted to estimate the optimal iodine concentration threshold for discriminating pathologic myocardium.
resultsIn total, 576 cardiac segments were evaluated. There were differences in mean iodine concentration (p < 0.001) between normal (2.56 ± 0.66 mg/mL), ischemic (1.98 ± 0.36 mg/dL) and infarcted segments (1.35 ± 0.57 mg/mL). A myocardium iodine concentration of 2.1 mg/mL represented the optimal threshold to discriminate between normal and pathologic myocardium (sensitivity 75 %, specificity 73.6 %, area under the curve 0.806). Excellent agreement was found in measured myocardium iodine concentration (intraclass correlation coefficient 0.814).
conclusionCardiac DECT-S with iodine quantification may be useful to differentiate healthy and ischemic or necrotic myocardium. KEY POINTS: • DECT-S allows for determination of myocardial iodine concentration as a quantitative perfusion parameter. • A high interobserver correlation exists in measuring myocardial iodine concentration with DECT-S. • Myocardial iodine concentration may be useful in the assessment of patients with CAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.