ArticlePloS one2015
Size of the Ovulatory Follicle Dictates Spatial Differences in the Oviductal Transcriptome in Cattle.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Organoids simulating the bovine oviduct mediate the embryo-maternal interface via extracellular vesicle-transmitted signaling.Human reproduction open · 2026Article
- Ovarian structures modulate cellular aggregation and gene expression in oviductal isthmus cells.Animal reproduction · 2026Article
- Three-Dimensional Magnetic Bioprinting Spheroids as an In Vitro Model to Study the Oviductal Physiology.Molecular reproduction and development · 2025Article
- Effect of the estrous cycle on zinc transporter expression in bovine cumulus-oocyte complexes and oviduct epithelial cells.Veterinary research communications · 2024Article
- Effect of estrous cycle phases on gene expression in bovine oviduct epithelial cells.Veterinary world · 2022Article
- Spatiotemporal profiling of the bovine oviduct fluid proteome around the time of ovulation.Scientific reports · 2022Article
- Steroidal Regulation of Oviductal microRNAs Is Associated with microRNA-Processing in Beef Cows.International journal of molecular sciences · 2021Article
- Changes in Oviductal Cells and Small Extracellular Vesicles miRNAs in Pregnant Cows.Frontiers in veterinary science · 2021Article
- A Comparative View on the Oviductal Environment during the Periconception Period.Biomolecules · 2020Review
- Possible roles of local oviductal estradiol-17β in luteal formation phase on the function of bovine oviductal epithelium.The Journal of veterinary medical science · 2019Article
- "Biological Adhesion" is a Significantly Regulated Molecular Process during Long-Term Primary In Vitro Culture of Oviductal Epithelial Cells (Oecs): A Transcriptomic and Proteomic Study.International journal of molecular sciences · 2019Article
- Relative effects of location relative to the corpus luteum and lactation on the transcriptome of the bovine oviduct epithelium.BMC genomics · 2019Article
- Review
- Can the antral follicular count modulate the gene expression of bovine oviducts in Aberdeen Angus and Nelore heifers?PloS one · 2018Article
- Oviductal transcriptional profiling of a bovine fertility model by next-generation sequencing.Genomics data · 2017Article
- Profiling of proteins secreted in the bovine oviduct reveals diverse functions of this luminal microenvironment.PloS one · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cattle, molecular control of oviduct receptivity to the embryo is poorly understood. Here, we used a bovine model for receptivity based on size of the pre-ovulatory follicle to compare oviductal global and candidate gene transcript abundance on day 4 of the estrous cycle. Growth of the pre-ovulatory follicle (POF) of Nelore (Bos indicus) cows was manipulated to produce two groups: large POF large corpus luteum (CL) group (LF-LCL; greater receptivity) and small POF-small CL group (SF-SCL). Oviductal samples were collected four days after GnRH-induced ovulation. Ampulla and isthmus transcriptome was obtained by RNA-seq, regional gene expression was assessed by qPCR, and PGR and ERa protein distribution was evaluated by immunohistochemistry. There was a greater abundance of PGR and ERa in the oviduct of LF-LCL animals thus indicating a greater availability of receptors and possibly sex steroids stimulated signaling in both regions. Transcriptomic profiles indicated a series of genes associated with functional characteristics of the oviduct that are regulated by the periovulatory sex steroid milieu and that potentially affect oviductal receptivity and early embryo development. They include tissue morphology changes (extra cellular matrix remodeling), cellular changes (proliferation), and secretion changes (growth factors, ions and metal transporters), and were enriched for the genes with increased expression in the LF-LCL group. In conclusion, differences in the periovulatory sex steroid milieu lead to different oviductal gene expression profiles that could modify the oviductal environment to affect embryo survival and development.
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