Evidence map›Paper›PMID 26699206›Full record

ArticleProteomics2016

The Pig PeptideAtlas: A resource for systems biology in animal production and biomedicine.

Marianne O Hesselager, Marius C Codrea, Zhi Sun, Eric W Deutsch, Tue B Bennike, Allan Stensballe, Louise Bundgaard, Robert L Moritz, Emøke Bendixen

Open access · goldAbstract read
In one paragraph

Article in Proteomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 57 citations in OpenAlex.

  1. Journal of proteome research · 2025
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  12. Porcine models of acute kidney injury.American journal of physiology. Renal physiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Marianne O HesselagerDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Marius C CodreaQuantitative Biology Center (QBiC), Eberhard Karls Universität, Tübingen, Germany.
Zhi SunInstitute for Systems Biology, Seattle, WA, USA.
Eric W DeutschInstitute for Systems Biology, Seattle, WA, USA.
Tue B BennikeDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Allan StensballeDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Louise BundgaardDepartment of Large Animal Sciences, University of Copenhagen, Copenhagen, Denmark.
Robert L MoritzInstitute for Systems Biology, Seattle, WA, USA.
Emøke BendixenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.
Institute for Systems Biology · USAalborg University · DKAarhus University · DKUniversity of Copenhagen · DKUniversity of Tübingen · DE

Funding

Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2006 to 2016
$30.6M
TrainingU54EB020406 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2014 to 2018
$12.5M
Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0M
Complete Human Peptide- and MRM-AtlasRC2HG005805 · NHGRI · INSTITUTE FOR SYSTEMS BIOLOGY · PI HOOD, LEROY E, MORITZ, ROBERT L · 2009 to 2010
$4.6M
FAIMS-Selected Reaction Monitoring to Quantitative Protein Networks in DiseaseS10RR027584 · NCRR · INSTITUTE FOR SYSTEMS BIOLOGY · PI MORITZ, ROBERT L · 2011 to 2011
$576k
NCRR NIH HHS S10 RR027584NCRR NIH HHS S10RR027584NHGRI NIH HHS RC2 HG005805NHGRI NIH HHS RC2HG005805NIBIB NIH HHS U54 EB020406NIBIB NIH HHS U54EB020406NIGMS NIH HHS 2P50GM076547NIGMS NIH HHS P50 GM076547NIGMS NIH HHS R01 GM087221NIGMS NIH HHS R01GM087221
6 · The paper itself

Abstract

Biological research of Sus scrofa, the domestic pig, is of immediate relevance for food production sciences, and for developing pig as a model organism for human biomedical research. Publicly available data repositories play a fundamental role for all biological sciences, and protein data repositories are in particular essential for the successful development of new proteomic methods. Cumulative proteome data repositories, including the PeptideAtlas, provide the means for targeted proteomics, system-wide observations, and cross-species observational studies, but pigs have so far been underrepresented in existing repositories. We here present a significantly improved build of the Pig PeptideAtlas, which includes pig proteome data from 25 tissues and three body fluid types mapped to 7139 canonical proteins. The content of the Pig PeptideAtlas reflects actively ongoing research within the veterinary proteomics domain, and this article demonstrates how the expression of isoform-unique peptides can be observed across distinct tissues and body fluids. The Pig PeptideAtlas is a unique resource for use in animal proteome research, particularly biomarker discovery and for preliminary design of SRM assays, which are equally important for progress in research that supports farm animal production and veterinary health, as for developing pig models with relevance to human health research.

Indexed as

Amino Acid SequenceAnimalsDatabases, ProteinData MiningInflammationMass SpectrometryMetabolic Networks and PathwaysProtein IsoformsProteomeProteomicsSerum Amyloid A ProteinSus scrofaSwineSwine DiseasesProtein IsoformsProteomeSerum Amyloid A ProteinAnimal modelBiomarkerPig PeptideAtlasProteomicsRepositories

Identifiers

PMID26699206
PMCPMC4786621
OpenAlexW2204819753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.