Evidence map›Paper›PMID 26699128›Full record

ArticlePloS one2015

Non-Catalytic RISCs and Kinetics Determine Mammalian siRNA Sub-Cellular Localization.

Fengmin Ji, Lianyun Liu, Ya-Hsin Tien, Yi-Hsien Peng, Hoong-Chien Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Fengmin JiInstitute of Biological Sciences and Biotechnology, Beijing Jiaotong University, Beijing 100044, China.
Lianyun LiuDepartment of Chemistry, Beijing Jiaotong University, Beijing 100044, China.
Ya-Hsin TienDepartment of Biomedical Sciences and Engineering, National Central University, Zhongli District, Taoyuan City 32001, Taiwan.
Yi-Hsien PengDepartment of Biomedical Sciences and Engineering, National Central University, Zhongli District, Taoyuan City 32001, Taiwan.
Hoong-Chien LeeDepartment of Biomedical Sciences and Engineering, National Central University, Zhongli District, Taoyuan City 32001, Taiwan.
National Central University · TWBeijing Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small interfering RNAs (siRNAs) are fundamental to the regulation of cell function. Much is known about its gene interfering mechanism, but a kinetic description of it is still lacking. Here, we derived a set of reaction-diffusion equations for multiple RNA-induced silencing complex (RISC) pathways that give quantitative temporal and spatial descriptions of the siRNA process in mammalian cell, and are able to correctly describe all salient experimentally observed patterns of sub-cellular siRNA localization, including those that, at first glance, appear irreconcilable. These results suggest siRNA sub-cellular localization mainly concerns the non-catalytic RISC-target complex, and is caused by the selectiveness of RISC-target interaction and the permeability of the nuclear membrane to siRNA strands but not to RISC-target complexes. Our method is expected to be useful in devising RNAi based cell regulation strategies.

Indexed as

AnimalsBiological TransportKineticsMammalsModels, BiologicalRNA-Induced Silencing ComplexRNA, Small InterferingRNA-Induced Silencing ComplexRNA, Small Interfering

Identifiers

PMID26699128
PMCPMC4689521
OpenAlexW2220727889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.