Evidence map›Paper›PMID 26699120›Full record

ArticleBMC genetics2015

Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study.

Sharon K Davis, Ruihua Xu, Samson Y Gebreab, Pia Riestra, Amadou Gaye, Rumana J Khan, James G Wilson, Aurelian Bidulescu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sharon K DavisNational Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. sharon.davis@nih.gov.
Ruihua XuNational Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. ruihua.xu@nih.gov.
Samson Y GebreabNational Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. samson.gebreab@nih.gov.
Pia RiestraNational Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. teresa.riestra@nih.gov.
Amadou GayeNational Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. amadou.gaye@nih.gov.
Rumana J KhanNational Human Genome Research Institute, Genomics of Metabolic, Cardiovascular and Inflammatory Disease Branch, Social Epidemiology Research Unit, 10 Center Drive, Bethesda, MD, 20892, USA. rumana.khan@nih.gov.
James G WilsonDepartment of Physiology, University of Mississippi Center, 2500 N State St, Jackson, MS, 39216, USA. jgwilson2@umc.edu.
Aurelian BidulescuIndiana University Bloomington, School of Public Health, 1025 E. 7th St, Suite 111, Bloomington, IN, 47405, USA. abidules@indiana.edu.
National Human Genome Research Institute · USIndiana University Bloomington · USJackson Memorial Hospital · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025008 · NCRR · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2007 to 2011
$29.0M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Cardiovascular Disease Preventive Intervention ProgramUH1HL073461 · NHLBI · MOREHOUSE SCHOOL OF MEDICINE · PI DAVIS, SHARON K · 2003 to 2010
$3.7M
Intramural NIH HHSNCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001108NCRR NIH HHS UL1 RR025008NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNHLBI NIH HHS UH1 HL073461
6 · The paper itself

Abstract

backgroundAfrican Americans experience disproportionately higher prevalence of type 2 diabetes and related risk factors. Little research has been done on the association of ADIPOQ gene on type 2 diabetes, plasma adiponectin, blood glucose, HOMA-IR and body mass index (BMI) in African Americans. The objective of our research was to assess such associations with selected SNPs. The study included a sample of 3,020 men and women from the Jackson Heart Study who had ADIPOQ genotyping information. Unadjusted and adjusted regression models with covariates were used with type 2 diabetes and related phenotypes as the outcome stratified by sex.

resultsThere was no association between selected ADIPOQ SNPs with type 2 diabetes, blood glucose, or BMI in men or women. There was a significant association between variant rs16861205 and lower adiponectin in women with minor allele A in the fully adjusted model (β(SE) p = -.13(0.05), 0.003). There was also a significant association with variant rs7627128 and lower HOMA-IR among men with minor allele A in the fully adjusted model (β(SE) p = -0.74(0.20), 0.0002).

conclusionsThese findings represent new insights regarding the association of ADIPOQ gene and type 2 diabetes and related phenotypes in African American men and women.

Indexed as

AdiponectinBlack or African AmericanBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseHumansInsulin ResistanceMaleMiddle AgedAdiponectinADIPOQ protein, humanBlood Glucose

Identifiers

PMID26699120
PMCPMC4690307
OpenAlexW2213118754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.