ArticleAnnals of biomedical engineering2016
A Model to Study Articular Cartilage Mechanical and Biological Responses to Sliding Loads.
Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- A framework to assess mechano-tribological, structural and biochemical properties of articular cartilage.Frontiers in bioengineering and biotechnology · 2026Article
- A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-Physiological Loads.Cells, tissues, organs · 2022Article
- Biotribological Tests of Osteochondral Grafts after Treatment with Pro-Inflammatory Cytokines.Cartilage · 2021Article
- A novel model of a biomechanically induced osteoarthritis-like cartilage for pharmacological in vitro studies.Journal of cellular and molecular medicine · 2021Article
- A MOVING CONTACT OF ARTICULATION ENHANCES THE BIOSYNTHETIC AND FUNCTIONAL RESPONSES OF ARTICULAR CARTILAGE.Biotribology (Oxford) · 2021Article
- Effects of Loading Conditions on Articular Cartilage in a Metal-on-Cartilage Pairing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Effect of osteochondral graft orientation in a biotribological test system.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Reducing uncertainty when using knee-specific finite element models by assessing the effect of input parameters.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- ESTABLISHING A LIVE CARTILAGE-ON-CARTILAGE INTERFACE FOR TRIBOLOGICAL TESTING.Biotribology (Oxford) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
In physiological conditions, joint function involves continuously moving contact areas over the tissue surface. Such moving contacts play an important role for the durability of the tissue. It is known that in pathological joints these motion paths and contact mechanics change. Nevertheless, limited information exists on the impact of such physiological and pathophysiological dynamic loads on cartilage mechanics and its subsequent biological response. We designed and validated a mechanical device capable of applying simultaneous compression and sliding forces onto cartilage explants to simulate moving joint contact. Tests with varying axial loads (1-4 kg) and sliding speeds (1-20 mm/s) were performed on mature viable bovine femoral condyles to investigate cartilage mechanobiological responses. High loads and slow sliding speeds resulted in highest cartilage deformations. Contact stress and effective cartilage moduli increased with increasing load and increasing speed. In a pilot study, changes in gene expression of extracellular matrix proteins were correlated with strain, contact stress and dynamic effective modulus. This study describes a mechanical test system to study the cartilage response to reciprocating sliding motion and will be helpful in identifying mechanical and biological mechanisms leading to the initiation and development of cartilage degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.