ArticleThe Journal of endocrinology2016
Sex-specific regulation of weight and puberty by the Lin28/let-7 axis.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Genome-wide association study of age at menarche in the Taiwan Biobank suggests NOL4 as a novel associated gene.Journal of human genetics · 2023Pooled it
- Reproductive Fitness and the Links to Chronic Disease and Systemic Aging.Physiology (Bethesda, Md.) · 2026Review
- Differential microRNA Expression Profiles in Girls with Idiopathic Central Precocious Puberty and Premature Thelarche.International journal of molecular sciences · 2026Article
- Testicular heterochrony in vgll3-mediated maturation age in Atlantic salmon.G3 (Bethesda, Md.) · 2025Article
- The hippo pathway: a molecular bridge between environmental cues and pace of life.BMC ecology and evolution · 2025Review
- Role of LIN28B in the Regulation of Ribosomal Biogenesis and Lipid Metabolism in Medulloblastoma Brain Cancer Cells.Proteomes · 2025Article
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.Hormones (Athens, Greece) · 2025Review
- Article
- Gene-environmental regulation of the postnatal post-mitotic neuronal maturation.Trends in genetics : TIG · 2024Review
- Integrated Transcriptome Analysis Reveals the Crucial mRNAs and miRNAs Related to Fecundity in the Hypothalamus of Yunshang Black Goats during the Luteal Phase.Animals : an open access journal from MDPI · 2022Article
- Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice.Reproductive biology and endocrinology : RB&E · 2022Article
- Postnatal developmental trajectory of sex-biased gene expression in the mouse pituitary gland.Biology of sex differences · 2022Article
- Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge.Biomolecules · 2022Review
- LIN28 Family in Testis: Control of Cell Renewal, Maturation, Fertility and Aging.International journal of molecular sciences · 2022Review
- LIN28A: A multifunctional versatile molecule with future therapeutic potential.World journal of biological chemistry · 2022Review
- Father absence, age at menarche, and genetic confounding: A replication and extension using a polygenic score.Development and psychopathology · 2022Article
- A review of the genetics and epigenetics of central precocious puberty.Frontiers in endocrinology · 2022Review
- Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABAScientific reports · 2021Article
- Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.Translational psychiatry · 2021Article
- Exposure to maternal high-fat diet induces extensive changes in the brain of adult offspring.Translational psychiatry · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Christina CorreDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
Gen ShinodaDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
Hao ZhuDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
Diana L CousminerDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada Division of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
Christine CrossmanDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
Christian BellissimoDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
Anna GoldenbergDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada Division of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
George Q DaleyDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada.
Mark R PalmertDivision of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada Division of EndocrinologyThe Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, CanadaDivision of Hematology/OncologyBoston Children's Hospital, Boston, Massachusetts, USADepartments of Pediatrics and Internal MedicineChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, Texas, USAInstitute for Molecular MedicineFinland (FIMM), University of Helsinki, Helsinki, FinlandGenetics and Genome Biology ProgramThe Hospital for Sick Children, Toronto, Ontario, CanadaDepartment of Computer ScienceUniversity of Toronto, Toronto, Ontario, CanadaDepartments of Paediatrics and PhysiologyThe University of Toronto, Toronto, Ontario, Canada mark.palmert@sickkids.ca.
Hospital for Sick Children · CABoston Children's Hospital · USUniversity of Toronto · CAThe University of Texas Southwestern Medical Center · US
Funding
Understanding the role of the lin28 paralogs and branching morphogenesisR01GM107536 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI DALEY, GEORGE Q · 2014 to 2017
$1.9MCanadian Institutes of Health ResearchNIGMS NIH HHS R01 GM107536
Abstract
Growth and pubertal timing differ in boys and girls. Variants in/near LIN28B associate with age at menarche (AAM) in genome-wide association studies and some AAM-related variants associate with growth in a sex-specific manner. Sex-specific growth patterns in response to Lin28b perturbation have been detected in mice, and overexpression of Lin28a has been shown to alter pubertal timing in female mice. To investigate further how Lin28a and Lin28b affect growth and puberty in both males and females, we evaluated Lin28b loss-of-function (LOF) mice and Lin28a gain-of-function (GOF) mice. Because both Lin28a and Lin28b can act via the conserved microRNA let-7, we also examined let-7 GOF mice. As reported previously, Lin28b LOF led to lighter body weights only in male mice while Lin28a GOF yielded heavier mice of both sexes. Let-7 GOF mice weighed less than controls, and males were more affected than females. Timing of puberty was assessed by vaginal opening (VO) and preputial separation (PS). Male Lin28b LOF and male let-7 GOF, but not female, mice displayed alteration of pubertal timing, with later PS than controls. In contrast, both male and female Lin28a GOF mice displayed late onset of puberty. Together, these data point toward a complex system of regulation by Lin28a, Lin28b, and let-7, in which Lin28b and let-7 can impact both puberty and growth in a sex-specific manner, raising the possibility that this pathway may contribute to differential regulation of male and female growth and puberty in humans.
Indexed as
Body WeightSex CharacteristicsSexual MaturationAnimalsBody CompositionDNA-Binding ProteinsFemaleGene ExpressionGlucoseMaleMiceMice, KnockoutMicroRNAsRNA-Binding ProteinsDNA-Binding ProteinsGlucoseLin28b protein, mouseLin-28 protein, mouseMicroRNAsmirnlet7 microRNA, mouseRNA-Binding Proteinslet-7Lin28pubertysex-specific
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.