Evidence map›Paper›PMID 26698361›Full record

ArticleLab on a chip2016

Experimental and numerical studies on standing surface acoustic wave microfluidics.

Zhangming Mao, Yuliang Xie, Feng Guo, Liqiang Ren, Po-Hsun Huang, Yuchao Chen, Joseph Rufo, Francesco Costanzo, Tony Jun Huang

Open access · greenAbstract read
In one paragraph

Article in Lab on a chip, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 86 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Acoustofluidic Engineering of Functional Vessel-on-a-Chip.ACS biomaterials science & engineering · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhangming MaoDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Yuliang XieDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu and Department of Chemical Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Feng GuoDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Liqiang RenDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Po-Hsun HuangDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Yuchao ChenDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Joseph RufoDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Francesco CostanzoDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Tony Jun HuangDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA. junhuang@psu.edu.
Pennsylvania State University · US

Funding

Standing Surface Acoustic Wave Based Cell Sorters for Maintaining Cell IntegrityR01GM112048 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2017
$1.1M
Validation of acoustic tweezers for single-cell analyses of purine metabolismR33EB019785 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2016
$1.1M
NIBIB NIH HHS 1R33EB019785-01NIBIB NIH HHS R33 EB019785NIGMS NIH HHS 1R01 GM112048-01A1NIGMS NIH HHS R01 GM112048
6 · The paper itself

Abstract

Standing surface acoustic waves (SSAW) are commonly used in microfluidics to manipulate cells and other micro/nano particles. However, except for a simple one-dimensional (1D) harmonic standing waves (HSW) model, a practical model that can predict particle behaviour in SSAW microfluidics is still lacking. Herein, we established a two-dimensional (2D) SSAW microfluidic model based on the basic theory in acoustophoresis and our previous modelling strategy to predict the acoustophoresis of microparticles in SSAW microfluidics. This 2D SSAW microfluidic model considers the effects of boundary vibrations, channel materials, and channel dimensions on the acoustic propagation; as an experimental validation, the acoustophoresis of microparticles under continuous flow through narrow channels made of PDMS and silicon was studied. The experimentally observed motion of the microparticles matched well with the numerical predictions, while the 1D HSW model failed to predict many of the experimental observations. Particularly, the 1D HSW model cannot account for particle aggregation on the sidewall in PDMS channels, which is well explained by our 2D SSAW microfluidic model. Our model can be used for device design and optimization in SSAW microfluidics.

Indexed as

Microfluidic Analytical TechniquesModels, TheoreticalSound

Identifiers

PMID26698361
PMCPMC4856433
OpenAlexW2216743084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.