Evidence map›Paper›PMID 26698018›Full record

SynthesisNeuroscience and biobehavioral reviews2016

Cognition and resting-state functional connectivity in schizophrenia.

Julia M Sheffield, Deanna M Barch

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuroscience and biobehavioral reviews, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Julia M SheffieldWashington University in St Louis, Department of Psychology, 1 Brookings Drive, St Louis, MO 63130, USA. Electronic address: Julia.sheffield@wustl.edu.
Deanna M BarchWashington University in St Louis, Department of Psychology, 1 Brookings Drive, St Louis, MO 63130, USA; Washington University in St Louis, Department of Psychiatry, 4940 Childrens Place, St Louis, MO 63110, USA; Washington University in St Louis, Department of Radiology, 224 Euclid Ave, St Louis, MO 63110, USA.

Funding

Schizophrenia, Prefrontal Cortex, and Emotion RegulationR01MH066031 · NIMH · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2004 to 2014
$4.1M
Training At The Interface of Psychology, Neuroscience, and GeneticsT32GM081739 · NIGMS · WASHINGTON UNIVERSITY · PI BARCH, DEANNA · 2007 to 2016
$2.1M
Trans-Diagnostic Relations Between Functional Brain Network Integrity and CognitionF31MH108309 · NIMH · WASHINGTON UNIVERSITY · PI SHEFFIELD, JULIA MAY · 2015 to 2016
$65k
NIGMS NIH HHS 5T32GM081739NIGMS NIH HHS T32 GM081739NIMH NIH HHS F31 MH108309NIMH NIH HHS F31 MH108309-01NIMH NIH HHS R01 MH066031
6 · The paper itself

Abstract

Individuals with schizophrenia consistently display deficits in a multitude of cognitive domains, but the neurobiological source of these cognitive impairments remains unclear. By analyzing the functional connectivity of resting-state functional magnetic resonance imaging (rs-fcMRI) data in clinical populations like schizophrenia, research groups have begun elucidating abnormalities in the intrinsic communication between specific brain regions, and assessing relationships between these abnormalities and cognitive performance in schizophrenia. Here we review studies that have reported analysis of these brain-behavior relationships. Through this systematic review we found that patients with schizophrenia display abnormalities within and between regions comprising (1) the cortico-cerebellar-striatal-thalamic loop and (2) task-positive and task-negative cortical networks. Importantly, we did not observe unique relationships between specific functional connectivity abnormalities and distinct cognitive domains, suggesting that the observed functional systems may underlie mechanisms that are shared across cognitive abilities, the disturbance of which could contribute to the "generalized" cognitive deficit found in schizophrenia. We also note several areas of methodological change that we believe will strengthen this literature.

Indexed as

Brain MappingBrainCognitionHumansMagnetic Resonance ImagingNeural PathwaysSchizophreniaCognitionCognitive dysmetriaDefault mode networkExecutive functioningFunctional brain networksFunctional connectivityGeneralized cognitive deficitGo/NoGoIQReinforcement learningResting-state fMRISchizophreniaTask-positive networks

Identifiers

PMID26698018
PMCPMC4731300

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.