ArticlePloS one2015
Differing Methods and Definitions Influence DALY estimates: Using Population-Based Data to Calculate the Burden of Convulsive Epilepsy in Rural South Africa.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The epidemiology of stroke in Africa: A systematic review of existing methods and new approaches.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
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- Burden of upper gastrointestinal cancers in the east of Golestan province (Golestan cohort study).Cancer reports (Hoboken, N.J.) · 2024Article
- The burden of epilepsy in the People's Republic of China from 1990 to 2019: epidemiological trends and comparison with the global burden of epilepsy.Frontiers in neurology · 2023Article
- A scoping review of burden of disease studies estimating disability-adjusted life years due to Taenia solium.PLoS neglected tropical diseases · 2022Article
- Disability-adjusted life years associated with chronic comorbidities among people living with and without HIV: Estimating health burden in British Columbia, Canada.PLOS global public health · 2022Article
- Estimating the health burden of aflatoxin attributable stunting among children in low income countries of Africa.Scientific reports · 2021Article
- Gender and Socioeconomic Disparities in Global Burden of Epilepsy: An Analysis of Time Trends From 1990 to 2017.Frontiers in neurology · 2021Article
- Disability-adjusted life years for severe acute malnutrition: implications of alternative model specifications.Public health nutrition · 2019Article
- Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.The Lancet. Neurology · 2019Article
- Clinical Application of Epilepsy Genetics in Africa: Is Now the Time?Frontiers in neurology · 2018Article
- Years of healthy life lost due to adverse pregnancy and childbirth outcomes among adolescent mothers in Thailand.AIMS public health · 2018Article
- Nitrobenzylthioinosine mimics adenosine to attenuate the epileptiform discharge of hippocampal neurons from epileptic rats.Oncotarget · 2017Article
- Management of acute seizures in children: A review with special consideration of care in resource-limited settings.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2017Review
- Disability-Adjusted Life Years for Maternal, Neonatal, and Nutritional Disorders in Korea.Journal of Korean medical science · 2016Article
- Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.Lancet (London, England) · 2016Article
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6 authors.
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Abstract
backgroundThe disability adjusted life year (DALY) is a composite measure of disease burden that includes both morbidity and mortality, and is relevant to conditions such as epilepsy that can limit productive functioning. The 2010 Global Burden of Disease (GBD) study introduced a number of new methods and definitions, including a prevalence-based approach and revised disability weights to calculate morbidity and new standard life expectancies to calculate premature mortality. We used these approaches, and local, population-based data, to estimate the burden of convulsive epilepsy in rural South Africa. METHODS &
findingsComprehensive prevalence, incidence and mortality data on convulsive epilepsy were collected within the Agincourt sub-district in rural northeastern South Africa between 2008 and 2012. We estimated DALYs using both prevalence- and incidence-based approaches for calculating years of life lived with disability. Additionally, we explored how changing the disease model by varying the disability weights influenced DALY estimates. Using the prevalence-based approach, convulsive epilepsy in Agincourt resulted in 332 DALYs (95% uncertainty interval (UI): 216-455) and 4.1 DALYs per 1,000 individuals (95%UI: 2.7-5.7) annually. Of this, 26% was due to morbidity while 74% was due to premature mortality. DALYs increased by 10% when using the incidence-based method. Varying the disability weight from 0.072 (treated epilepsy, seizure free) to 0.657 (severe epilepsy) caused years lived with disability to increase from 18 (95%UI: 16-19) to 161 (95%UI: 143-170).
conclusionsDALY estimates are influenced by both the methods applied and population parameters used in the calculation. Irrespective of method, a significant burden of epilepsy is due to premature mortality in rural South Africa, with a lower burden than rural Kenya. Researchers and national policymakers should carefully interrogate the methods and data used to calculate DALYs as this will influence policy priorities and resource allocation.
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