Evidence map›Paper›PMID 26697375›Full record

ArticleGenomics data2015

Identifying rhesus macaque gene orthologs using heterospecific human CNV probes.

Jillian Ng, Joseph N Fass, Blythe Durbin-Johnson, David Glenn Smith, Sree Kanthaswamy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics data, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Comparative medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jillian NgMolecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA.
Joseph N FassGenome Center Bioinformatics Core, University of California, Davis, CA, USA.
Blythe Durbin-JohnsonGenome Center Bioinformatics Core, University of California, Davis, CA, USA.
David Glenn SmithMolecular Anthropology Laboratory, Department of Anthropology, University of California, Davis, CA, USA ; California National Primate Research Center, University of California, Davis, CA, USA.
Sree KanthaswamyCalifornia National Primate Research Center, University of California, Davis, CA, USA ; School of Mathematics and Natural Sciences, Arizona State University (ASU) at the West Campus, Glendale, AZ, USA.

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HYDE, DALLAS MELVIN · 1985 to 2011
$126.2M
GENETICALLY DEFINED HERPES/RETROVIRUS SPF MACAQUES: AIDS: VACCINE DVMTU24RR018144 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI LERCHE, NICHOLAS WILLIAM · 2002 to 2011
$15.7M
GENETIC MANAGEMENT OF MECAQUES BY DNA RFLP ANALYSISR24RR005090 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI SMITH, DAVID GLENN · 1988 to 2011
$3.7M
Development, Management and Use of a SNP Map for Rhesus MacaqueR24RR025871 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SMITH, DAVID GLENN · 2009 to 2011
$1.6M
NCRR NIH HHS P51 RR000169NCRR NIH HHS R24 RR005090NCRR NIH HHS R24 RR025871NCRR NIH HHS U24 RR018144NIH HHS P51 OD011107
6 · The paper itself

Abstract

We used the Affymetrix(®) Genome-Wide Human SNP Array 6.0 to identify heterospecific markers and compare copy number and structural genomic variation between humans and rhesus macaques. Over 200,000 human copy number variation (CNV) probes were mapped to a Chinese and an Indian rhesus macaque sample. Observed genomic rearrangements and synteny were in agreement with the results of a previously published genomic comparison between humans and rhesus macaques. Comparisons between each of the two rhesus macaques and humans yielded 206 regions with copy numbers that differed by at least two fold in the Indian rhesus macaque and human, 32 in the Chinese rhesus macaque and human, and 147 in both rhesus macaques. The detailed genomic map and preliminary CNV data are useful for better understanding genetic variation in rhesus macaques, identifying derived changes in human CNVs that may have evolved by selection, and determining the suitability of rhesus macaques as human models for particular biomedical studies.

Indexed as

Copy number variation (CNV)Heterospecific sequence mapHomo sapiensMacaca mulatta

Identifiers

PMID26697375
PMCPMC4664757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.