Evidence map›Paper›PMID 26697339›Full record

ArticleGenomics data2015

The effect of Vdr gene ablation on global gene expression in the mouse placenta.

Sam Buckberry, Fleur Spronk, Rebecca L Wilson, Jessica A Laurence, Tina Bianco-Miotto, Shalem Leemaqz, Sean O'Leary, Paul H Anderson, Claire T Roberts

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics data, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sam BuckberryRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia.
Fleur SpronkRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia.
Rebecca L WilsonRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia.
Jessica A LaurenceRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia.
Tina Bianco-MiottoRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia ; School of Agriculture, Food and Wine, University of Adelaide, Adelaide, Australia.
Shalem LeemaqzRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia.
Sean O'LearyRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia.
Paul H AndersonSchool of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, Australia.
Claire T RobertsRobinson Research Institute, The University of Adelaide, School of Paediatrics and Reproductive Health, Adelaide, Australia.
The University of Adelaide · AUUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of vitamin D are mediated through the vitamin D receptor (VDR), a predominantly nuclear receptor, expressed in numerous tissues including the placenta. VDR and the retinoid X receptor (RXR) form a dimer complex which binds to genomic vitamin D responsive elements located primarily in promoter regions and recruit cell-specific transcription factor complexes which regulate the expression of numerous genes. To investigate the role of VDR on regulating placental gene expression, mice heterozygous (+/-) for an ablated Vdr allele (C57Bl6 strain B6.129S4-VDRtm1Mbd/J, Jackson Laboratory) were mated to generate Vdr(+/+), Vdr(+/-) and Vdr (-/-) fetuses and placental samples were collected at day 18.5 of pregnancy. RNA was isolated from placental tissue with global gene expression measured using Affymetrix Mouse Gene 2.1 ST Arrays to assess the effects of VDR on global gene expression in the placenta. All raw array data are deposited in Gene Expression Omnibus (GEO) under accession GSE61583.

Indexed as

Gene expressionPlacentaVDRVitamin D

Identifiers

PMID26697339
PMCPMC4664714
OpenAlexW1177159244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.