ArticleJournal of adolescent and young adult oncology2015
Pediatric and Teen Ovarian Tissue Removed for Cryopreservation Contains Follicles Irrespective of Age, Disease Diagnosis, Treatment History, and Specimen Processing Methods.
Article in Journal of adolescent and young adult oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ovarian Tissue Freezing for Fertility Preservation in Pre-Pubertal Children Facing a Fertility Threatening Medical Diagnosis or Treatment Regimen
Ovarian Tissue Cryopreservation for Fertility Preservation in Post-Pubertal Children Facing a Fertility Threatening Diagnosis or Treatment Regimen
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Fertility preservation in girls and adolescents with Turner syndrome: lessons for reproductive care in differences of sex development - a mini-review.Frontiers in endocrinology · 2026Review
- Advancing human ovarian biology in tandem with clinical care: considerations for collecting ovarian tissue for research after oophorectomy for tissue cryopreservation.Frontiers in endocrinology · 2026Review
- Protective Effects of Gallic Acid Against Lead Acetate- Induced Toxicity in Mice Ovary: Focus on Apoptosis, Inflammation, and Folliculogenesis.Food science & nutrition · 2025Article
- Approaches to Reduce Toxicity in Pediatric Brain Tumors.Current oncology (Toronto, Ont.) · 2025Review
- Classification system of human ovarian follicle morphology: recommendations of the National Institute of Child Health and Human Development - sponsored ovarian nomenclature workshop.Fertility and sterility · 2025Article
- Immature Follicular Origins and Disrupted Oocyte Growth Pathways Contribute to Decreased Gamete Quality During Reproductive Juvenescence in Mice.Frontiers in cell and developmental biology · 2021Article
- Spatial Analysis of Growing Follicles in the Human Ovary to Inform Tissue Engineering Strategies.Tissue engineering. Part A · 2020Article
- Ovarian Stimulation Is Safe and Effective for Patients with Gynecologic Cancer.Journal of adolescent and young adult oncology · 2020Article
- Ovarian stimulation is a safe and effective fertility preservation option in the adolescent and young adult population.Journal of assisted reproduction and genetics · 2020Article
- Impact of first-line cancer treatment on the follicle quality in cryopreserved ovarian samples from girls and young women.Human reproduction (Oxford, England) · 2019Article
- The ovarian germinal reserve and apoptosis-related proteins in the infant and adolescent human ovary.Journal of ovarian research · 2019Article
- Laparoscopic unilateral oophorectomy for ovarian tissue cryopreservation in children.Journal of pediatric surgery · 2019Article
- Review
- Immuno-Isolating Dual Poly(ethylene glycol) Capsule Prevents Cancer Cells from Spreading Following Mouse Ovarian Tissue Auto-Transplantation.Regenerative medicine frontiers · 2019Article
- The National Physicians Cooperative: transforming fertility management in the cancer setting and beyond.Future oncology (London, England) · 2018Article
- Ovarian tissue cryopreservation in young females through the Oncofertility Consortium's National Physicians Cooperative.Future oncology (London, England) · 2018Article
- A review of reported surgical techniques in fertility preservation for prepubertal and adolescent females facing a fertility threatening diagnosis or treatment.American journal of surgery · 2017Review
- Egg Quality during the Pubertal Transition-Is Youth All It's Cracked Up to Be?Frontiers in endocrinology · 2017Article
- Fertility Lost-Fertility Found: Narratives from the Leading Edge of Oncofertility.Narrative inquiry in bioethics · 2017Article
- Ovarian tissue transport to expand access to fertility preservation: from animals to clinical practice.Reproduction (Cambridge, England) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeFertility preservation in a pediatric and teen female population is challenging because standard technologies of egg and embryo freezing may not be possible due to premenarcheal status. Ovarian tissue cryopreservation (OTC) with the intent of future ovarian tissue transplantation or in vitro follicle growth may be the only option to preserve fertility. The purpose of this study was to add to the general understanding of primordial follicle dynamics in young patients.
methodsFirst, the unique infrastructure of the Oncofertility Consortium National Physicians Cooperative (OC-NPC) is described, which simultaneously drives clinical fertility preservation and basic research to explore and expand the reproductive options for those in need. Then, the OC-NPC research resource is used to perform a histological evaluation of ovarian tissue from 24 participants younger than 18 years of age.
resultsPrimordial follicles, which comprise the ovarian reserve, were observed in all participant tissues, irrespective of variables, including age, diagnosis, previous treatment history, tissue size, and tissue processing methods. Primordial follicles were present in ovarian tissue, even in participants who had a previous history of exposure to chemotherapy and/or radiation treatment regimens, which placed them at risk for iatrogenic infertility or premature ovarian failure.
conclusionPrimordial follicles were observed in ovarian tissue from all participants examined, despite population and tissue heterogeneity. These results increase the understanding of human follicle dynamics and support OTC as a promising fertility preservation modality in the young female population. Future studies to evaluate follicle quality within these tissues are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.