Evidence map›Paper›PMID 26697222›Full record

ReviewJournal of pregnancy2015

Physiologic Course of Female Reproductive Function: A Molecular Look into the Prologue of Life.

Joselyn Rojas, Mervin Chávez-Castillo, Luis Carlos Olivar, María Calvo, José Mejías, Milagros Rojas, Jessenia Morillo, Valmore Bermúdez

Open access · goldAbstract readReview
In one paragraph

Review in Journal of pregnancy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. NR4A1-Driven Granulosa Cell Ferroptosis Contributes to Obesity-Related Ovarian Dysfunction and Metformin-Mediated Ovarian Protection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. The Role of Nitric Oxide on Male and Female Reproduction.The Malaysian journal of medical sciences : MJMS · 2022
    Review
  14. Review
  15. Combining Bioinformatics and Experiments to IdentifyDiagnostics (Basel, Switzerland) · 2020
    Article
  16. Article
  17. Control of Germline Stem Cell Lineages by Diet and Physiology.Results and problems in cell differentiation
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Joselyn RojasEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
Mervin Chávez-CastilloEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
Luis Carlos OlivarEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
María CalvoEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
José MejíasEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
Milagros RojasEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
Jessenia MorilloEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
Valmore BermúdezEndocrine-Metabolic Research Center, "Dr. Félix Gómez", Faculty of Medicine, University of Zulia, Maracaibo 4004, Zulia, Venezuela.
University of Zulia · VE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic, endocrine, and metabolic mechanisms underlying female reproduction are numerous and sophisticated, displaying complex functional evolution throughout a woman's lifetime. This vital course may be systematized in three subsequent stages: prenatal development of ovaries and germ cells up until in utero arrest of follicular growth and the ensuing interim suspension of gonadal function; onset of reproductive maturity through puberty, with reinitiation of both gonadal and adrenal activity; and adult functionality of the ovarian cycle which permits ovulation, a key event in female fertility, and dictates concurrent modifications in the endometrium and other ovarian hormone-sensitive tissues. Indeed, the ultimate goal of this physiologic progression is to achieve ovulation and offer an adequate environment for the installation of gestation, the consummation of female fertility. Strict regulation of these processes is important, as disruptions at any point in this evolution may equate a myriad of endocrine-metabolic disturbances for women and adverse consequences on offspring both during pregnancy and postpartum. This review offers a summary of pivotal aspects concerning the physiologic course of female reproductive function.

Indexed as

AndrogensCell DeathEmbryonic InductionFemaleFertilityGonadal Steroid HormonesHumansMeiosisMenstrual CycleMitosisNeurosecretory SystemsOogenesisOvaryOvulationOvumPubertyAndrogensGonadal Steroid Hormones

Identifiers

PMID26697222
PMCPMC4678088
OpenAlexW2189561149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.