ReviewJournal of parasitology research2015
Human Coinfection with Borrelia burgdorferi and Babesia microti in the United States.
Review in Journal of parasitology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Profound Hemolytic Anemia in Babesiosis With Lyme Disease Coinfection and Occult Strongyloidiasis.Cureus · 2026Article
- Coinfection ecology and pathogen emergence in aApplied and environmental microbiology · 2026Article
- Coinfection Ecology and Pathogen Emergence in amedRxiv : the preprint server for health sciences · 2025Article
- Update on North American tick-borne diseases and how to diagnose them.Journal of clinical microbiology · 2025Review
- Temporal Dynamic Interplay of Mouse Proteome during ProtozoanJournal of proteome research · 2025Article
- TICKHUNTER: A Targeted Hybridization-Capture Sequencing Approach for the Detection and Characterization of Tick-borne Pathogens and Blood Meals.bioRxiv : the preprint server for biology · 2025Article
- A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases.Scientific reports · 2025Article
- Development, Optimization, and Validation of a Quantitative PCR Assay forPathogens (Basel, Switzerland) · 2024Article
- Prevalence ofMicroorganisms · 2024Article
- Beyond Human Babesiosis: Prevalence and Association ofOpen forum infectious diseases · 2024Article
- Co-infection dynamics ofInfection and immunity · 2024Article
- Review
- Global prevalence ofBMJ open · 2024Article
- Transmission risk evaluation of transfusion blood containing low-densityFrontiers in cellular and infection microbiology · 2024Article
- Babesiosis: Analysis of the Evidence for Infections in the United Kingdom.International journal of general medicine · 2024Review
- Exploring the relationship of supernumerary recurrent renal calculi formation and tick-borne infections: a case report.Frontiers in cellular and infection microbiology · 2024Article
- Babesiosis concurrent with multiple abscesses fromHeliyon · 2023Article
- Neurologic Complications of Babesiosis, United States, 2011-2021.Emerging infectious diseases · 2023Article
- Procalcitonin as a Potential Biomarker in the Study of Babesiosis Caused byPathogens (Basel, Switzerland) · 2022Article
- The Cross-Species Immunity During AcuteFrontiers in cellular and infection microbiology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Borrelia burgdorferi, the causative agent of Lyme disease, and Babesia microti, a causative agent of babesiosis, are increasingly implicated in the growing tick-borne disease burden in the northeastern United States. These pathogens are transmitted via the bite of an infected tick vector, Ixodes scapularis, which is capable of harboring and inoculating a host with multiple pathogens simultaneously. Clinical presentation of the diseases is heterogeneous and ranges from mild flu-like symptoms to near-fatal cardiac arrhythmias. While the reason for the variability is not known, the possibility exists that concomitant infection with both B. burgdorferi and B. microti may synergistically increase disease severity. In an effort to clarify the current state of understanding regarding coinfection with B. burgdorferi and B. microti, in this review, we discuss the geographical distribution and pathogenesis of Lyme disease and babesiosis in the United States, the immunological response of humans to B. burgdorferi or B. microti infection, the existing knowledge regarding coinfection disease pathology, and critical factors that have led to ambiguity in the literature regarding coinfection, in order to eliminate confusion in future experimental design and investigation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.