ArticleJournal of dental research, dental clinics, dental prospects2015
Evaluation of Antimicrobial Effects of Different Concentrations of Triple Antibiotic Paste on Mature Biofilm of Enterococcus faecalis.
Article in Journal of dental research, dental clinics, dental prospects, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Comparison of the biocidal efficacy of sodium dichloro-iso-cyanurate, double antibiotic pastes and calcium hydroxide as intra-canal medicaments for regenerative endodontic therapy: an ex-vivo study.BMC oral health · 2026Article
- Article
- Human Stem Cells of Apical Papilla Viability Following the Removal of Triple Antibiotic Paste in a 3D Root Canal Culture Model.European endodontic journal · 2025Article
- Bactericidal Effect of Triple Antibiotic Paste against Enterococcus faecalis in Dentinal Tubules: An Ex Vivo Study.European endodontic journal · 2024Article
- Antimicrobial Effect of Nano-Calcium Hydroxide on the Four- and Six-Week-Old Intra-CanalJournal of dentistry (Shiraz, Iran) · 2023Article
- Immediate and Delayed Post Space Preparations in Endodontically Treated Teeth: A Scoping Review.BMC oral health · 2022Article
- Evaluation of Antibacterial Effects of Cold Atmospheric Plasma, Calcium Hydroxide, and Triple Antibiotic Paste onJournal of lasers in medical sciences · 2022Article
- Effect of three intracanal medicaments used in pulp regeneration on the push-out bond strength of mineral trioxide aggregate and calcium-enriched mixture: AnJournal of dental research, dental clinics, dental prospects · 2022Article
- Antimicrobial effects of different concentrations of simvastatin versus triple antibiotic paste onJournal of dental research, dental clinics, dental prospects · 2022Article
- Responses of oral-microflora-exposed dental pulp to capping with a triple antibiotic paste or calcium hydroxide cement in mouse molars.Regenerative therapy · 2020Article
- The Effects of Intracanal Irrigants and Medicaments on Dental-Derived Stem Cells Fate in Regenerative Endodontics: An update.Stem cell reviews and reports · 2020Review
- Antimicrobial Efficacy of Intracanal Medicaments againstInternational journal of dentistry · 2020Article
- Effect of Intracanal Medicaments on Pull-Out Bond Strength of Fiber Post Cemented with a Self-Adhesive System.European journal of dentistry · 2019Article
- Comparison of Antibacterial Effects of Photodynamic Therapy, Modified Triple Antibiotic Paste and Calcium Hydroxide on Root Canals Infected WithJournal of lasers in medical sciences · 2019Article
- A Review on Triple Antibiotic Paste as a Suitable Material Used in Regenerative Endodontics.Iranian endodontic journal · 2018Article
- Effects of different intra canal medicaments on the push out bond strength of endodontic sealers.Journal of clinical and experimental dentistry · 2017Article
- Antimicrobial efficacy of different concentration of sodium hypochlorite on the biofilm ofJournal of clinical and experimental dentistry · 2016Article
- Evaluation of tissue inflammatory response of four intracanal medicament - An animal study.Journal of conservative dentistry : JCDArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims. Triple antibiotic paste (TAP) is widely used in endodontics for root canal disinfection, particularly in regenerative procedures. The aim of this in vitro study was to evaluate the antimicrobial effects of different concentrations of TAP at 1-, 2-, 3-, and 4-week intervals on mature Enterococcus faecalis biofilm. Materials and methods. A total of 287 extracted one-rooted human central incisors were infected with E. faecalis ATCC 29212 after removing the crown and preparation. The root canal space was filled with one of the 0.01-, 0.1-, 1-, 10-, 100-, and 1000-mg/mL concentrations of TAP or normal saline (control). The root canal dentin was sampled after 1, 2, 3, and 4 weeks. The dentinal shavings were cultured on Mueller-Hinton agar plates after serial dilutions. The classic colony-forming unit (CFU) counting technique was used to determine remaining bacterial counts. Data were analyzed by using the two-way ANOVA, post hoc Tukey tests and one-way ANOVA (P<0.05). Results. TAP completely eliminated E. faecalis biofilms at all the intervals at concentrations of 1000, 100, and 10 mg/mL, whereas 1-, 0.1-, and 0.01-mg/mL TAP resulted in significant reduction of CFU means compared with the control group. There were no statistically significant differences between the four time intervals. Conclusion. Use of lower concentrations of TAP at short term could eradicate E. faecalis biofilm and decrease high-concentration side effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.