ArticleFrontiers in plant science2015
Functional Divergence of APETALA1 and FRUITFULL is due to Changes in both Regulation and Coding Sequence.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 45 citations in OpenAlex.
- Comparative Analysis of Floral Transcriptomes inPlants (Basel, Switzerland) · 2025Article
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- The phytochrome-interacting factor genes PIF1 and PIF4 are functionally diversified due to divergence of promoters and proteins.The Plant cell · 2024Article
- Analysis of pea mutants reveals the conserved role ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Differential gene expression during floral transition in pineapple.Plant direct · 2023Article
- Floral Homeotic Factors: A Question of Specificity.Plants (Basel, Switzerland) · 2023Review
- FRUITFULL-like genes regulate flowering time and inflorescence architecture in tomato.The Plant cell · 2022Article
- Genome-wide identification, interaction of the MADS-box proteins inFrontiers in plant science · 2022Article
- TCP Transcription Factors Involved in Shoot Development of Ma Bamboo (Frontiers in plant science · 2022Article
- Comprehensive Analysis of FiveInternational journal of molecular sciences · 2021Article
- Utilizing MIKC-type MADS-box protein SOC1 for yield potential enhancement in maize.Plant cell reports · 2021Article
- Genetic containment in vegetatively propagated forest trees: CRISPR disruption of LEAFY function in Eucalyptus gives sterile indeterminate inflorescences and normal juvenile development.Plant biotechnology journal · 2021Article
- Divergent Functional Diversification Patterns in the SEP/AGL6/AP1 MADS-Box Transcription Factor Superclade.The Plant cell · 2019Article
- Article
- Expression and regulatory asymmetry of retained Arabidopsis thaliana transcription factor genes derived from whole genome duplication.BMC evolutionary biology · 2019Article
- Identification and analysis of glutathione S-transferase gene family in sweet potato reveal divergent GST-mediated networks in aboveground and underground tissues in response to abiotic stresses.BMC plant biology · 2017Article
- Homeotic MADS-box genes encoding LeMADS-MC orthologues in wild tomato species (genus Solanum).Doklady. Biochemistry and biophysics · 2017Article
- Expression patterns ofEvoDevo · 2017Article
- Evolution of Gene Duplication in Plants.Plant physiology · 2016Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplications are prevalent in plants, and functional divergence subsequent to duplication may be linked with the occurrence of novel phenotypes in plant evolution. Here, we examine the functional divergence of Arabidopsis thaliana APETALA1 (AP1) and FRUITFULL (FUL), which arose via a duplication correlated with the origin of the core eudicots. Both AP1 and FUL play a role in floral meristem identity, but AP1 is required for the formation of sepals and petals whereas FUL is involved in cauline leaf and fruit development. AP1 and FUL are expressed in mutually exclusive domains but also differ in sequence, with unique conserved motifs in the C-terminal domains of the proteins that suggest functional differentiation. To determine whether the functional divergence of AP1 and FUL is due to changes in regulation or changes in coding sequence, we performed promoter swap experiments, in which FUL was expressed in the AP1 domain in the ap1 mutant and vice versa. Our results show that FUL can partially substitute for AP1, and AP1 can partially substitute for FUL; thus, the functional divergence between AP1 and FUL is due to changes in both regulation and coding sequence. We also mutated AP1 and FUL conserved motifs to determine if they are required for protein function and tested the ability of these mutated proteins to interact in yeast with known partners. We found that these motifs appear to play at best a minor role in protein function and dimerization capability, despite being strongly conserved. Our results suggest that the functional differentiation of these two paralogous key transcriptional regulators involves both differences in regulation and in sequence; however, sequence changes in the form of unique conserved motifs do not explain the differences observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.