ArticleFrontiers in microbiology2015
An Antimicrobial Metabolite from Bacillus sp.: Significant Activity Against Pathogenic Bacteria Including Multidrug-Resistant Clinical Strains.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Optimization, characterization, and mechanistic evaluation of iturin and surfactin like, broad spectrum antimicrobial lipopeptides from Bacillus subtilis RKEA1 isolated from Acanthus ilicifolius.World journal of microbiology & biotechnology · 2026Article
- Genomic and Phenotypic Characterization of Sandstorm-Derived AirborneAntibiotics (Basel, Switzerland) · 2026Article
- Molecular Profiling of Soil-DerivedCurrent issues in molecular biology · 2026Article
- Community matters: stress tolerance and survival ofFrontiers in microbiology · 2026Article
- Role ofJournal of microbiology and biotechnology · 2025Review
- Characterization of soil-derived Bacillus subtilis metabolites against breast cancer: In vitro and in silico studies.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025Article
- Antibacterial Activity of Metabolites of EndophyticInternational journal of microbiology · 2025Article
- The EpiphyteBiomolecules · 2024Article
- Antibacterial activity of soil-isolatedAfrican journal of laboratory medicine · 2023Article
- Purification and Characterization of Novel Anti-MRSA Peptides Produced byMolecules (Basel, Switzerland) · 2022Article
- Identification and Characterization of a Potential Antimicrobial Peptide Isolated from SoilTropical medicine and infectious disease · 2022Article
- Soil-Associated Bacillus Species: A Reservoir of Bioactive Compounds with Potential Therapeutic Activity against Human Pathogens.Microorganisms · 2021Article
- Bacteriocin isolated from the natural inhabitant of Allium cepa against Staphylococcus aureus.World journal of microbiology & biotechnology · 2021Article
- Article
- Diversity and Bioactive Potential of Actinobacteria from Unexplored Regions of Western Ghats, India.Microorganisms · 2020Article
- Isolation and Characterization of Fengycins Produced byFrontiers in microbiology · 2020Article
- Antimicrobial and Cytotoxic Properties of Bioactive Metabolites Produced by Streptomyces cavourensis YBQ59 Isolated from Cinnamomum cassia Prels in Yen Bai Province of Vietnam.Current microbiology · 2018Article
- Structural Elucidation and Molecular Docking of a Novel Antibiotic Compound from CyanobacteriumFrontiers in microbiology · 2016Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the cell free modified tryptone soya broth (pH 7.4 ± 0.2) of Bacillus subtilis URID 12.1 showed significant antimicrobial activity against multidrug-resistant strains of Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes and Enterococcus faecalis. The partially purified antimicrobial molecule was found to be resistant to extremes of pH and temperatures and also to higher concentrations of trypsin and proteinase K. The antimicrobial molecule was purified by a three-step method that included reversed-phase high performance liquid chromatography (RP-HPLC). The minimum inhibitory concentration (MIC) values were determined for 14 species of bacteria using a microbroth dilution technique. The HPLC-purified fraction showed the MICs ranging from 0.5 to 16 μg/ml for methicillin and vancomycin-resistant Staphylococcus aureus (MVRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) strains. The molecular mass of the antimicrobial compound was determined to be 842.37 Da. The same antimicrobial fraction showed negligible haemolytic activity against human red blood cells even at a concentration as high as 100 μg/ml. Because of its significant antimicrobial activity at low MIC values coupled with its non-haemolytic property, it may prove to be a novel antimicrobial lead molecule.
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