ReviewFrontiers in psychology2015
Eye Movement in Unipolar and Bipolar Depression: A Systematic Review of the Literature.
Review in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07057024 (Contribution of Virtual Reality Eye Tracking in the Identification of Schizophrenia, Bipolar and Depression), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Contribution of Virtual Reality Eye Tracking in the Identification of Schizophrenia, Bipolar and Depression
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- Transdiagnostic eye-tracking biomarkers of inattention across psychiatric disorders: a systematic review.BMC psychiatry · 2025Pooled it
- Naturalistic Eye Movement Tasks in Parkinson's Disease: A Systematic Review.Journal of Parkinson's disease · 2024Pooled it
- Eye-Tracking in Bipolar Disorder: A Methodology-Focused Narrative Review.Medicina (Kaunas, Lithuania) · 2026Review
- The impact of mental health symptoms on relational memory performance.Cognitive, affective & behavioral neuroscience · 2026Article
- Multimodal Virtual Reality Assessment of Medication Effects in Attention-Deficit/Hyperactivity Disorder and Its Distinction From Depression: Cross-Sectional Study.JMIR human factors · 2026Article
- Ocular Motor Abnormalities in Functional Neurological Disorder: A Video-Oculography Study.Movement disorders clinical practice · 2026Article
- Multimodal clinical, sleep, and autonomic correlates across the depressive spectrum: a cross-sectional study.Frontiers in psychology · 2026Article
- Threat-related attentional bias in subjects with different looming cognitive styles: Evidence based on eye-tracking study.World journal of psychiatry · 2025Article
- Reliability and reactivity of heart rate variability and pupillometry in response to controlled autonomic perturbations in university students.Behavior research methods · 2025Article
- Transformer-based fusion model for mild depression recognition with EEG and pupil area signals.Medical & biological engineering & computing · 2025Article
- Refining smart healthcare care for mental health and substance use disorders: A patient-centred, evidence-based approach.World journal of psychiatry · 2025Article
- Gaze behaviors during free viewing revealed differences in visual salience processing across four major psychiatric disorders: a mega-analysis study of 1012 individuals.Molecular psychiatry · 2025Article
- Identifying depression with mixed features: the potential value of eye-tracking features.Frontiers in neurology · 2025Article
- Study protocol TransTAM: Transdiagnostic research into emotional disorders and cognitive-behavioral therapy of the adaptive mind.BMC psychiatry · 2024Article
- An historical overview of artificial intelligence for diagnosis of major depressive disorder.Frontiers in psychiatry · 2024Review
- Divergent pattern of functional connectivity within the dorsal attention network differentiates schizophrenia and bipolar disorder patients.Frontiers in psychiatry · 2024Article
- Diagnosing and tracking depression based on eye movement in response to virtual reality.Frontiers in psychiatry · 2024Article
- The Vestibulocerebellum and the Shattered Self: a Resting-State Functional Connectivity Study in Posttraumatic Stress Disorder and Its Dissociative Subtype.Cerebellum (London, England) · 2023Article
- Eye-tracking in adult depression: protocol for a systematic review and meta-analysis.BMJ open · 2023Article
- Clinical utility of square-wave jerks in neurology and psychiatry.Frontiers in ophthalmology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe analysis of eye movements (EM) by eye-tracking has been carried out for several decades to investigate mood regulation, emotional information processing, and psychomotor disturbances in depressive disorders.
methodA systematic review of all English language PubMed articles using the terms "saccadic eye movements" OR "eye-tracking" AND "depression" OR "bipolar disorders" was conducted using PRISMA guidelines. The aim of this review was to characterize the specific alterations of EM in unipolar and bipolar depression.
resultsFindings regarding psychomotor disturbance showed an increase in reaction time in prosaccade and antisaccade tasks in both unipolar and bipolar disorders. In both disorders, patients have been reported to have an attraction for negative emotions, especially for negative pictures in unipolar and threatening images in bipolar disorder. However, the pattern could change with aging, elderly unipolar patients disengaging key features of sad and neutral stimuli. METHODological limitations generally include small sample sizes with mixed unipolar and bipolar depressed patients.
conclusionEye movement analysis can be used to discriminate patients with depressive disorders from controls, as well as patients with bipolar disorder from patients with unipolar depression. General knowledge concerning psychomotor alterations and affective regulation strategies associated with each disorder can also be gained thanks to the analysis. Future directions for research on eye movement and depression are proposed in this review.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.