ArticleFrontiers in aging neuroscience2015
Platelet Rich Plasma Therapy in Non-insertional Achilles Tendinopathy: The Efficacy is Reduced in 60-years Old People Compared to Young and Middle-Age Individuals.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Platelet-rich plasma in tendon-related disorders: results and indications.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018Pooled it
- The role of tendon and ligament vasculature in ageing and injury.Biogerontology · 2026Review
- Integrating platelet-rich plasma therapy into nursing practice: a review of biological mechanisms and clinical applications.Frontiers in bioengineering and biotechnology · 2026Review
- Association of theInternational journal of molecular sciences · 2025Article
- TheInternational journal of molecular sciences · 2024Article
- Recent developments in Achilles tendon risk-analyzing rupture factors for enhanced injury prevention and clinical guidance: Current implications of regenerative medicine.Journal of orthopaedic translation · 2024Review
- Correlation of bioactive components of platelet rich plasma derived from human female adult peripheral blood and umbilical cord blood with age.Scientific reports · 2023Article
- Polymorphic Variants of theJournal of clinical medicine · 2022Article
- What Role DoesJournal of clinical medicine · 2022Article
- Application of Orthobiologics in Achilles Tendinopathy: A Review.Life (Basel, Switzerland) · 2022Review
- Radiofrequency Microtenotomy or Physical Therapy for Achilles Tendinopathy: Results of a Randomized Clinical Trial.Orthopaedic journal of sports medicine · 2021Article
- Why PRP works only on certain patients with tennis elbow? Is PDGFB gene a key for PRP therapy effectiveness? A prospective cohort study.BMC musculoskeletal disorders · 2021Article
- Factors associated with positive outcomes of platelet-rich plasma therapy in Achilles tendinopathy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Article
- Platelet Concentrates in Musculoskeletal Medicine.International journal of molecular sciences · 2020Review
- Investigating the effect of age on platelet ultrastructure using transmission electron microscopy.International wound journal · 2019Article
- Myths and Facts of In-Office Regenerative Procedures for Tendinopathy.American journal of physical medicine & rehabilitation · 2019Review
- Biology of Tendon Stem Cells and Tendon in Aging.Frontiers in genetics · 2019Review
- Platelet-rich plasma (PRP) treatment of noninsertional Achilles tendinopathy in a two case series: no significant difference in effect between leukocyte-rich and leukocyte-poor PRP.Orthopedic research and reviews · 2019Article
- Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner.Bone & joint research · 2019Article
- Platelet-rich plasma: combinational treatment modalities for musculoskeletal conditions.Frontiers of medicine · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelet Rich Plasma (PRP) has shown positive and long-lasting effects in patients with tendinopathies. However, information about age-related differences in the clinical outcome is limited. Aim of this retrospective study was to compare the efficacy of PRP therapy in young and elderly subjects suffering for Achilles tendinopathy. MATERIALS AND
methodPatients with recalcitrant non-insertional Achilles tendinopathy were enrolled. Clinical (VISA-A) and instrumental (ultrasonography) data were collected at baseline and after 1, 3, 6, and 12 months. PRP injections (once a week for 3 weeks) were performed in sterile conditions and under ultrasound (US) control.
resultsForty-four subjects (29 young: mean age 39.5 ± 6.9; 15 elderly: mean age 61.5 ± 5.3) were retrospectively evaluated. At baseline, no significant differences were observed in the clinical and US parameters. Throughout the whole length of the study, a significant increase of VISA-A score was seen in both groups (from 50.3 ± 8.8 to 76.1 ± 6.6 in the young group, and from 48.7 ± 7.6 to 61.1 ± 9.4 in the elderly group); however, the infra-groups comparison showed better results in young patients, compared to the aged counterpart.
conclusionOur results show that PRP is less effective in aged people. This finding can be ascribed to several biochemical and biomechanical differences documented in tendons of young and elderly subjects (reduced number and functionality of tenocytes and tenoblasts), which becomes more evident in the long-term tissue healing. However, prospective trials, using different PRP preparations and enrolling a larger number of subjects, are needed to draw more sound and definitive conclusions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.