ArticleFrontiers in aging neuroscience2015
Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 45 citations in OpenAlex.
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- Cyrene: a novel geroprotective compound that extends lifespan and healthspan in C. elegans and Drosophila.npj aging · 2025Article
- An mTOR inhibitor discovery system using drug-sensitized yeast.GeroScience · 2025Article
- Coffee as a Source of Antioxidants and an Elixir of Youth.Antioxidants (Basel, Switzerland) · 2025Review
- Coffee consumption and cardiometabolic health: a comprehensive review of the evidence.GeroScience · 2024Review
- Meloidogyne incognita genes involved in the repellent behavior in response to ascr#9.Scientific reports · 2024Article
- Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span ofmicroPublication biology · 2024Article
- Role of 7-methylxanthine in myopia prevention and control: a mini-review.International journal of ophthalmology · 2023Review
- Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia.Human molecular genetics · 2022Article
- AdoR-1 (Adenosine Receptor) Contributes to Protection against Paraquat-Induced Oxidative Stress inOxidative medicine and cellular longevity · 2022Article
- Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials inMolecules (Basel, Switzerland) · 2021Review
- Pharmacological Effect of Caffeine onArchives of Razi Institute · 2021Article
- Article
- Long-Term Caffeine Intake Exerts Protective Effects on Intestinal Aging by Regulating Vitellogenesis and Mitochondrial Function in an AgedNutrients · 2021Article
- Theanine Improves High-Dose Epigallocatechin-3-Gallate-Induced Lifespan Reduction inFoods (Basel, Switzerland) · 2021Article
- Coffee Extends Yeast Chronological Lifespan through Antioxidant Properties.International journal of molecular sciences · 2020Article
- Caffeine reduces deficits in mechanosensation and locomotion induced by L-DOPA and protects dopaminergic neurons in a transgenicPharmaceutical biology · 2020Article
- Effects of Phosphoethanolamine Supplementation on Mitochondrial Activity and Lipogenesis in a Caffeine IngestionNutrients · 2020Article
- Review
- Plant and fungal products that extend lifespan inMicrobial cell (Graz, Austria) · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm's exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.