ArticleFrontiers in cellular neuroscience2015
Control of Phasic Firing by a Background Leak Current in Avian Forebrain Auditory Neurons.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Clinical effects of passive cable theory applied via subthreshold electrical stimulation in chronic neck pain: A randomized trial.PM & R : the journal of injury, function, and rehabilitation · 2026Trial
- Input-Specific Organization of Intrinsic Excitability Expands Coding Capacity of Fast-Spiking Auditory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A complex social-acoustical environment supports development and maintenance in the zebra finch auditory pallium.Journal of neurophysiology · 2025Article
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Decoding the mechanism of proanthocyanidins in central analgesia: redox regulation and KCNK3 blockade.Experimental & molecular medicine · 2025Article
- Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats.Journal of bioenergetics and biomembranes · 2024Article
- Estrogens rapidly shape synaptic and intrinsic properties to regulate the temporal precision of songbird auditory neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Resurgent NaNature communications · 2021Article
- Aromatase and nonaromatase neurons in the zebra finch secondary auditory forebrain are indistinct in their song-driven gene induction and intrinsic electrophysiological properties.The European journal of neuroscience · 2021Article
- Genetically identified neurons in avian auditory pallium mirror core principles of their mammalian counterparts.Current biology : CB · 2021Article
- Electrophysiological Characterization of Regular and Burst Firing Pyramidal Neurons of the Dorsal Subiculum in an Angelman Syndrome Mouse Model.Frontiers in cellular neuroscience · 2021Article
- Experience- and Sex-Dependent Intrinsic Plasticity in the Zebra Finch Auditory Cortex during Song Memorization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Early Auditory Experience Modifies Neuronal Firing Properties in the Zebra Finch Auditory Cortex.Frontiers in neural circuits · 2020Article
- Rapid and long-lasting improvements in neural discrimination of acoustic signals with passive familiarization.PloS one · 2019Article
- A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations.Biophysical journal · 2017Article
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
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5 authors at 3 institutions in 3 countries.
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Abstract
Central neurons express a variety of neuronal types and ion channels that promote firing heterogeneity among their distinct neuronal populations. Action potential (AP) phasic firing, produced by low-threshold voltage-activated potassium currents (VAKCs), is commonly observed in mammalian brainstem neurons involved in the processing of temporal properties of the acoustic information. The avian caudomedial nidopallium (NCM) is an auditory area analogous to portions of the mammalian auditory cortex that is involved in the perceptual discrimination and memorization of birdsong and shows complex responses to auditory stimuli We performed in vitro whole-cell patch-clamp recordings in brain slices from adult zebra finches (Taeniopygia guttata) and observed that half of NCM neurons fire APs phasically in response to membrane depolarizations, while the rest fire transiently or tonically. Phasic neurons fired APs faster and with more temporal precision than tonic and transient neurons. These neurons had similar membrane resting potentials, but phasic neurons had lower membrane input resistance and time constant. Surprisingly phasic neurons did not express low-threshold VAKCs, which curtailed firing in phasic mammalian brainstem neurons, having similar VAKCs to other NCM neurons. The phasic firing was determined not by VAKCs, but by the potassium background leak conductances, which was more prominently expressed in phasic neurons, a result corroborated by pharmacological, dynamic-clamp, and modeling experiments. These results reveal a new role for leak currents in generating firing diversity in central neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.