ArticleFrontiers in cellular neuroscience2015
The Shaping of Two Distinct Dendritic Spikes by A-Type Voltage-Gated K(+) Channels.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Thalamocortical feedback selectively controls pyramidal neuron excitability.Nature communications · 2025Article
- Kv4.2 Regulates Basal Synaptic Strength by Inhibiting R-Type Calcium Channels in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Voltage-Gated Potassium ChanneleNeuro · 2025Article
- Integrated scRNAseq analyses of mouse cochlear supporting cells reveal the involvement of Ezh2 in hair cell regeneration.Molecular biology reports · 2024Article
- Therapeutic effects of phlorotannins in the treatment of neurodegenerative disorders.Frontiers in molecular neuroscience · 2023Review
- Short-term postsynaptic plasticity facilitates predictive tracking in continuous attractors.Frontiers in computational neuroscience · 2023Article
- Hippocampal interlamellar cell-cell connectome that counts.Journal of cellular physiology · 2022Review
- Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus.iScience · 2021Article
- Article
- Transient Potassium Channels: Therapeutic Targets for Brain Disorders.Frontiers in cellular neuroscience · 2019Review
- Long term potentiation, but not depression, in interlamellar hippocampus CA1.Scientific reports · 2018Article
- A Postsynaptic Role for Short-Term Neuronal Facilitation in Dendritic Spines.Frontiers in cellular neuroscience · 2016Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dendritic ion channels have been a subject of intense research in neuroscience because active ion channels in dendrites shape input signals. Ca(2+)-permeable channels including NMDA receptors (NMDARs) have been implicated in supralinear dendritic integration, and the IA conductance in sublinear integration. Despite their essential roles in dendritic integration, it has remained uncertain whether these conductance coordinate with, or counteract, each other in the process of dendritic integration. To address this question, experiments were designed in hippocampal CA1 neurons with a recent 3D digital holography system that has shown excellent performance for spatial photoactivation. The results demonstrated a role of IA as a key modulator for two distinct dendritic spikes, low- and high-threshold Ca(2+) spikes, through a preferential action of IA on Ca(2+)-permeable channel-mediated currents, over fast AMPAR-mediated currents. It is likely that the rapid kinetics of IA provides feed-forward inhibition to counteract the regenerative Ca(2+) channel-mediated dendritic excitability. This research reveals one dynamic ionic mechanism of dendritic integration, and may contribute to a new understanding of neuronal hyperexcitability embedded in several neural diseases such as epilepsy, fragile X syndrome and Alzheimer's disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.